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1. WO2006067414 - GLYCINE TRANSPORT INHIBITORS

Publication Number WO/2006/067414
Publication Date 29.06.2006
International Application No. PCT/GB2005/004937
International Filing Date 21.12.2005
Chapter 2 Demand Filed 09.08.2006
IPC
C07C 233/78 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
C07D 409/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 215/50 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
50attached in position 4
C07D 333/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur atom
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
14Radicals substituted by singly bound hetero atoms other than halogen
20by nitrogen atoms
A61K 31/166 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
166having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A61K 31/381 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
CPC
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
02for disorders of the vagina
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • BOZZOLI, Andrea [IT]/[IT] (UsOnly)
  • BRADLEY, Daniel, Marcus [GB]/[GB] (UsOnly)
  • COULTON, Steven [GB]/[GB] (UsOnly)
  • GILPIN, Martin, Leonard [GB]/[GB] (UsOnly)
  • MACRITCHIE, Jacqueline, Anne [GB]/[GB] (UsOnly)
  • PORTER, Roderick, Alan [GB]/[GB] (UsOnly)
  • THEWLIS, Kevin, Michael [GB]/[GB] (UsOnly)
Inventors
  • BOZZOLI, Andrea
  • BRADLEY, Daniel, Marcus
  • COULTON, Steven
  • GILPIN, Martin, Leonard
  • MACRITCHIE, Jacqueline, Anne
  • PORTER, Roderick, Alan
  • THEWLIS, Kevin, Michael
Agents
  • CONNELL, Anthony, Christopher
Priority Data
0428231.523.12.2004GB
0509204.405.05.2005GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GLYCINE TRANSPORT INHIBITORS
(FR) COMPOSES
Abstract
(EN) The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
(FR) La présente invention concerne des composés de formule (I), ou des sels ou des solvates de ces composés, ainsi que leur utilisation pour fabriquer des médicaments destinés à traiter des troubles neurologiques et neuropsychiatriques, en particulier des psychoses, une démence ou un trouble déficitaire de l'attention. L'invention concerne en outre des procédés de fabrication de ces composés et des formulations pharmaceutiques contenant ces composés.
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