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1. WO2006055855 - METHOD OF IMAGING CELL DEATH IN VIVO

Publication Number WO/2006/055855
Publication Date 26.05.2006
International Application No. PCT/US2005/042020
International Filing Date 17.11.2005
IPC
A61K 51/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
08Peptides, e.g. proteins
CPC
A61K 51/088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
088conjugates with carriers being peptides, polyamino acids or proteins
Applicants
  • MCW RESEARCH FOUNDATION, INC. [US]/[US] (AllExceptUS)
  • ZHAO, Ming [US]/[US] (UsOnly)
Inventors
  • ZHAO, Ming
Agents
  • REN, Zhibin
Priority Data
60/629,60719.11.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF IMAGING CELL DEATH IN VIVO
(FR) PROCEDE SERVANT A PRENDRE L'IMAGE DE L'APOPTOSE IN VIVO
Abstract
(EN) The present invention relates to a method and a kit for detecting cell death or another condition characterized by an increase in the extracellular level of phosphatidylserine in a mammalian subject. The method involves administering a radionuclide-labeled compound that comprises a C2 domain of a protein or an active variant thereof and measuring radiation emission from the radionuclide in the subject to obtain an image of radiation emission, wherein the site of cell death or said condition can be determined from the image. The kit can contain a radionuclide-labeled compound comprising a C2 domain or an active variant thereof and an instruction on administering the compound into a mammalian subject to image cell death or said condition.
(FR) L'invention concerne un procédé et une trousse servant à détecter l'apoptose, ou un autre état caractérisé par une augmentation du niveau extracellulaire de phosphatidylsérine chez un mammifère. Ce procédé consiste à administrer un composé marqué par un radionuclide et comprenant un domaine C2 de protéine ou d'une variante active de celle-ci, puis à mesurer l'émission du rayonnement émis par le radionuclide afin d'obtenir une image dudit rayonnement, ce qui permet de déterminer, à partir de l'image, l'emplacement de l'apoptose ou dudit état. La trousse peut contenir un composé marqué par un radionuclide et comprenant un domaine C2 ou sa variante active, ainsi que des instructions d'administration dudit composé à un mammifère.
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