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1. WO2006055623 - METHOD AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF MALARIA INFECTIONS

Publication Number WO/2006/055623
Publication Date 26.05.2006
International Application No. PCT/US2005/041509
International Filing Date 17.11.2005
IPC
C07K 1/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
C07K 2/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2Peptides of undefined number of amino acids; Derivatives thereof
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/015 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
002Protozoa antigens
015Hemosporidia antigens, e.g. Plasmodium antigens
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/445
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
44from protozoa
445Plasmodium
Y02A 50/30
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection, e.g. against extreme weather
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applicants
  • DREXEL UNIVERSITY [US]/[US] (AllExceptUS)
  • BERGMAN, Lawrence, W. [US]/[US] (UsOnly)
  • VAIDYA, Akhil, B. [IN]/[US] (UsOnly)
Inventors
  • BERGMAN, Lawrence, W.
  • VAIDYA, Akhil, B.
Agents
  • LICATA, Jane, Massey
Priority Data
60/628,57217.11.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF MALARIA INFECTIONS
(FR) METHODES ET COMPOSITIONS DE PREVENTION ET DE TRAITEMENT D'INFECTIONS PALUDIQUES
Abstract
(EN) Isolated proteins and nucleic acid sequence encoding such protein that interacts with a red blood cell to be invaded by a malaria parasite and link with a component of the actin-myosin based machinery of the malaria parasite are provided. In addition methods for identifying agents which inhibit the function of these proteins as chemotherapeutic and/or immunologic agents for treatment and prevention of malaria infections are provided. Compositions for treatment and prevention of malaria infections and methods for preventing and treating malaria infections are also provided.
(FR) L'invention concerne des protéines isolées ainsi qu'une séquence nucléotidique codant une telle protéine ayant une interaction avec un globule rouge destiné à être envahi par un parasite paludique et un lien avec un constituant du mécanisme basé sur l'actine-myosine du parasite paludique. De plus, l'invention concerne des procédés d'identification d'agents qui inhibent la fonction de ces protéines en tant qu'agents chimiothérapeutiques et/ou immunologiques de traitement et de prévention d'infections paludiques. L'invention concerne aussi des compositions de traitement et de prévention d'infections paludiques ainsi que des méthodes de prévention et de traitement d'infections paludiques.
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