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1. (WO2006055260) USE OF SCF AND G-CSF IN THE TREATMENT OF CEREBRAL ISCHEMIA AND NEUROLOGICAL DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/055260 International Application No.: PCT/US2005/039792
Publication Date: 26.05.2006 International Filing Date: 04.11.2005
IPC:
A61K 38/19 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
ZHAO, Li-Ru [CN/US]; US (UsOnly)
KESSLER, John [US/US]; US (UsOnly)
SINGHAL, Seema [US/US]; US (UsOnly)
JAYESH, Mehta [US/US]; US (UsOnly)
NORTHWESTERN UNIVERSITY [US/US]; 633 Clark Street Evanston, Illinois 60208, US (AllExceptUS)
Inventors:
ZHAO, Li-Ru; US
KESSLER, John; US
SINGHAL, Seema; US
JAYESH, Mehta; US
Agent:
JANULIS, Lynn, L.; MARSHALL, GERSTEIN & BORUN LLP 233 S. Wacker Drive, Suite 6300 Sears Tower Chicago, Illinois 60606-6357, US
Priority Data:
60/625,18905.11.2004US
Title (EN) USE OF SCF AND G-CSF IN THE TREATMENT OF CEREBRAL ISCHEMIA AND NEUROLOGICAL DISORDERS
(FR) UTILISATION DE SCF ET DE SCF DANS LE TRAITEMENT DE L'ISCHEMIE CEREBRALE ET DES TROUBLES NEUROLOGIQUES
Abstract:
(EN) The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G­CSF) polypeptide, in the prevention or treatment of injury to the brain after cerebral ischemia or neurological disorder. More particularly, the invention provides methods of improving neurological function and outcome after stroke by the administration of SCF polypeptide, alone and in combination with G-CSF polypeptide. This treatment can be used alone or in combination with other well-known methods of treatment of cerebral ischemia and neurological disorders in a mammal.
(FR) L'invention concerne l'utilisation du polypeptide SCF (facteur des cellules souches), seul ou combiné au polypeptide G-CSF (facteur stimulant les colonies de granulocytes), pour la prévention ou le traitement des lésions cérébrales consécutives à une ischémie cérébrale ou à un trouble neurologique. D'une manière plus spécifique, l'invention concerne des méthodes qui permettent d'améliorer la fonction neurologique et les séquelles d'une apoplexie grâce à l'administration du polypeptide SCF, seul ou combiné au polypeptide G-CSF. Ce traitement peut être utilisé seul ou combiné à d'autres méthodes bien connues de traitement de l'ischémie cérébrale et des troubles neurologiques chez un mammifère.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)