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1. WO2006054964 - PREPARATION AND CHARACTERIZATION OF FORMULATIONS IN A HIGH THROUGHPUT MODE

Publication Number WO/2006/054964
Publication Date 26.05.2006
International Application No. PCT/US2004/037735
International Filing Date 12.11.2004
IPC
B01J 19/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
G01N 35/02 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
02using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
CPC
B01J 19/0046
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
B01J 2219/00283
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00281Individual reactor vessels
00283Reactor vessels with top opening
B01J 2219/00308
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00306Reactor vessels in a multiple arrangement
00308interchangeably mounted in racks or blocks
B01J 2219/00319
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00306Reactor vessels in a multiple arrangement
00313the reactor vessels being formed by arrays of wells in blocks
00319the blocks being mounted in stacked arrangements
B01J 2219/00344
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00331Details of the reactor vessels
00333Closures attached to the reactor vessels
00344Caps
B01J 2219/00484
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00479Means for mixing reactants or products in the reaction vessels
00484by shaking, vibrating or oscillating of the reaction vessels
Applicants
  • SYNGENTA LIMITED [GB]/[GB] (AllExceptUS)
  • BYSOUTH, Stephen, Robert [GB]/[US] (UsOnly)
  • HITE, Sidney, Wilson [US]/[US] (UsOnly)
  • BOHARA, Amrish [IN]/[NL] (UsOnly)
  • NETTLETON-HAMMOND, John, Henry [GB]/[GB] (UsOnly)
  • BERGSTROM, Karin, Ingegard [SE]/[SE] (UsOnly)
  • LANDHAM, Rowena [GB]/[GB] (UsOnly)
  • LUKKARI, Ingrid, Gunborg [SE]/[SE] (UsOnly)
Inventors
  • BYSOUTH, Stephen, Robert
  • HITE, Sidney, Wilson
  • BOHARA, Amrish
  • NETTLETON-HAMMOND, John, Henry
  • BERGSTROM, Karin, Ingegard
  • LANDHAM, Rowena
  • LUKKARI, Ingrid, Gunborg
Agents
  • SYNGENTA LIMITED
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION AND CHARACTERIZATION OF FORMULATIONS IN A HIGH THROUGHPUT MODE
(FR) PREPARATION ET CARACTERISATION DE FORMULATIONS EN MODE HAUT DEBIT
Abstract
(EN) The invention is an automated robotic system for the production and testing of formulations at a very high throughput. It is an integrated system of hardware and software capable of preparing and evaluating hundreds of emulsions per day. The system can formulate aqueous solutions (SL), oil in water emulsions (EW), suspo-emulsions (SE), micro capsule suspensions (CS), micro-emulsions (ME), and suspension concentrates (SC) at the 1 ml to 25 ml scale. The system can process emulsions rapidly in an automated way and enable very flexible formulation recipes to be introduced. The system allows chemists to generate experimental samples of varying recipe and method to be conducted in parallel with projected throughput of up to 1200 formulations processed and characterized per day. Materials and consumables can be distributed from storage storage systems to the work stations where dispensing of ingredients in various states can be performed, including solids, liquids, gels, pastes, suspensions and waxes. The emulsions formed can be characterized using methods including phase diagnosis, turbidity analysis, viscosity and particle sizing using automated test equipment. An integrated module can also perform Tank Mix Compatibility testing in high throughput mode. The modular system allows future processes and tests to be added, either to a station, or as a new station. The software capability includes tracking of processes from start to finish and the integration of analytical data with the as-designed and as-formulated experimental results.
(FR) Cette invention concerne un système robotique automatisé pour la production et la vérification de formulations à un très haut débit. Il s'agit d'un système intégré (matériel et logiciel) permettant de préparer et d'évaluer des centaines d'émulsions par jour. Le système peut formuler des solutions aqueuses (SL), des émulsions aqueuses (EW), des émulsions en suspension (SE), des suspensions de micro-capsules (CS), des micro-émulsions (ME) et des suspensions concentrées (SC) dans une échelle de 1 à 25 ml. Il peut traiter des émulsions de manière rapide et automatisée et permet d'entrer des recettes de formulation très diverses. Des chimistes peuvent utiliser le système pour générer des échantillons expérimentaux de différentes recettes et un procédé à conduire en parallèle avec un débit prévu allant jusqu'à 1200 formulations traitées et caractérisées par jour. Il est possible de distribuer des matières et des consommables des systèmes de stockage aux postes de travail, où les ingrédients peuvent être distribués dans divers états, notamment solides, liquides, gels, pâtes, suspensions et cires. Les émulsions formées peuvent être caractérisées au moyen de procédés tels que le diagnostic de phase et l'analyse de turbidité, de viscosité ou de granulométrie à l'aide de matériel de test automatisé. Un module intégré permet également d'effectuer un test de compatibilité de mélange en cuve en mode haut débit. Le système modulaire permet d'ajouter, par la suite, des processus et des tests à un poste existant ou en tant que nouveau poste. Les fonctions logicielles comprennent le suivi complet des processus et l'intégration des données analytiques aux résultats expérimentaux tels qu'issus de la conception ou de la formulation.
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