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1. WO2006052886 - METABOLITES OF CERTAIN [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AND METHODS OF PREPARATION AND USE THEREOF

Publication Number WO/2006/052886
Publication Date 18.05.2006
International Application No. PCT/US2005/040289
International Filing Date 04.11.2005
IPC
C07D 471/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
06Peri-condensed systems
C07H 15/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
26Acyclic or carbocyclic radicals, substituted by hetero rings
A61K 31/551 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/7024 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
A61K 31/704 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
16Central respiratory analeptics
A61P 15/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
06Antiabortive agents; Labour repressants
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • BACH II, Alvin, C. [US]/[US] (UsOnly)
  • RAMAMOORTHY, P., Sivaramakrishnan [IN]/[US] (UsOnly)
  • TONG, Zeen [US]/[US] (UsOnly)
  • WANG, Jim [CN]/[US] (UsOnly)
  • DEMAIO, William [US]/[US] (UsOnly)
  • JORDAN, Ronald, A. [US]/[US] (UsOnly)
  • STACK, Gary, Paul [US]/[US] (UsOnly)
  • WANG, Youchu [CA]/[CA] (UsOnly)
Inventors
  • BACH II, Alvin, C.
  • RAMAMOORTHY, P., Sivaramakrishnan
  • TONG, Zeen
  • WANG, Jim
  • DEMAIO, William
  • JORDAN, Ronald, A.
  • STACK, Gary, Paul
  • WANG, Youchu
Agents
  • STRAHER, Michael, P.
Priority Data
60/625,33505.11.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METABOLITES OF CERTAIN [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AND METHODS OF PREPARATION AND USE THEREOF
(FR) METABOLITES DE CERTAINS DERIVES DE [1,4]DIAZEPINO[6,7,1-IJ] QUINOLINE ET PROCEDES DE PREPARATION ET D'UTILISATION DE CEUX-CI
Abstract
(EN) The invention relates to metabolites of certain [1,4]diazepino[6,7,1-i˜]quinoline derivatives and methods of preparation and use thereof. Specifically, the invention relates to compounds of formula I wherein the various substituents are defined herein. The invention also provides pharmaceutical compositions including compounds of formula I, methods of making such compounds, and methods of using such compounds.
(FR) Cette invention concerne des métabolites de certains dérivés de [1,4]diazepino[6,7,1-i˜]quinoline, ainsi que des procédés permettant de les préparer et de les utiliser. Plus spécifiquement, cette invention concerne des composés représentés par la formule I, les divers substituants étant définis dans la description. Cette invention concerne également des compositions pharmaceutiques contenant les composés représentés par la formule I, des procédés permettant de préparer de tels composés ainsi que des procédés permettant de les utiliser.
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