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1. WO2006051797 - THERAPEUTIC AGENT FOR INTERSTITIAL CYSTITIS

Publication Number WO/2006/051797
Publication Date 18.05.2006
International Application No. PCT/JP2005/020499
International Filing Date 09.11.2005
IPC
A61K 31/222 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
222with compounds having aromatic groups, e.g. dipivefrine, ibopamine
A61P 13/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
A61P 25/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
CPC
A61K 31/222
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
222with compounds having aromatic groups, e.g. dipivefrine, ibopamine
A61K 31/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
235having an aromatic ring attached to a carboxyl group
24having an amino or nitro group
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
Applicants
  • キッセイ薬品工業株式会社 KISSEI PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 海藤 功一 KAIDOH, Kouichi [JP]/[JP] (UsOnly)
  • 赤羽 敏 AKAHANE, Satoshi [JP]/[JP] (UsOnly)
Inventors
  • 海藤 功一 KAIDOH, Kouichi
  • 赤羽 敏 AKAHANE, Satoshi
Priority Data
2004-32599210.11.2004JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) THERAPEUTIC AGENT FOR INTERSTITIAL CYSTITIS
(FR) AGENT THÉRAPEUTIQUE POUR LA CYSTOPATHIE INTERSTITIELLE SOUS-MUQUEUSE
(JA) 間質性膀胱炎の治療薬
Abstract
(EN) A therapeutic agent for interstitial cystitis, characterized by containing a phenoxyacetic acid derivative represented by the following general formula (I): [Chemical formula 1] (I) (wherein R1 represents hydroxy or lower alkoxy) or a pharmacologically acceptable salt of the derivative. The phenoxyacetic acid derivative represented by the general formula (I) or pharmacologically acceptable salt or a hydrate or solvate thereof each functions to selectively stimulate a &bgr;3-adrenergic receptor and has remarkable inhibitory activity against a capsaicin-sensitive sensory nerve. They can hence be used as a preventive or therapeutic agent for interstitial cystitis and overactive bladder accompanied by a pain, other diseases in which a capsaicin-sensitive sensory nerve participates (e.g., acute or chronic, systemic or local pains or inflammation), irritable bowel syndrome (IBS), etc.
(FR) L'invention concerne un agent thérapeutique pour la cystopathie interstitielle sous-muqueuse, caractérisé en ce qu'il contient un dérivé de l'acide phénoxyacétique représenté par la formule générale (I) suivante : [Formule chimique 1] (I) (dans laquelle R1 représente un hydroxy ou un alcoxy inférieur) ou un sel acceptable du point de vue pharmacologique du dérivé. Le dérivé de l'acide phénoxyacétique représenté par la formule générale (I) ou un sel ou hydrate ou solvate acceptable du point de vue pharmacologique de celui-ci servent chacun à stimuler sélectivement un récepteur adrénergique &bgr;3 et possèdent une activité inhibitrice remarquable vis-à-vis d'un nerf sensitif sensible à la capsaïcine. Ils peuvent donc être utilisés comme agent préventif ou thérapeutique contre la cystopathie interstitielle sous-muqueuse et une vessie hyperactive accompagnée d'une douleur, d'autres maladies dans lesquelles participe le nerf sensitif sensible à la capsaïcine (par exemple des douleurs ou une inflammation aiguës ou chroniques, systémiques ou locales), le syndrome du côlon irritable (SCI), etc.
(JA) not available
Latest bibliographic data on file with the International Bureau