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1. WO2006051069 - DEFECTIVE INFLUENZA VIRUS PARTICLES

Publication Number WO/2006/051069
Publication Date 18.05.2006
International Application No. PCT/EP2005/055808
International Filing Date 08.11.2005
Chapter 2 Demand Filed 02.06.2006
IPC
C12N 7/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
A61K 39/145 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
CPC
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • SOLVAY PHARMACEUTICALS B.V. [NL]/[NL] (AllExceptUS)
  • ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM [NL]/[NL] (AllExceptUS)
  • DE WIT, Emmie [NL]/[NL] (UsOnly)
  • SPRONKEN, Monique I.J. [NL]/[NL] (UsOnly)
  • FOUCHIER, Ron A.M. [NL]/[NL] (UsOnly)
  • OSTERHAUS, Albert D.M.E. [NL]/[NL] (UsOnly)
Inventors
  • DE WIT, Emmie
  • SPRONKEN, Monique I.J.
  • FOUCHIER, Ron A.M.
  • OSTERHAUS, Albert D.M.E.
Agents
  • AERTS, Rob, J.
Priority Data
04105696.111.11.2004EP
05105708.127.06.2005EP
60/626,87812.11.2004US
60/694,43128.06.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DEFECTIVE INFLUENZA VIRUS PARTICLES
(FR) PARTICULES DU VIRUS DE LA GRIPPE DÉFECTIF
Abstract
(EN) The invention relates to the field of influenza virus and the vaccination against flu. The invention provides a conditionally defective influenza virus particle having seven different influenza nucleic acid segments. The invention also provides a conditionally defective influenza virus particle lacking an influenza nucleic acid segment selected from the group of segments essentially encoding acidic polymerase (PA), the basic polymerase 1 (PB1 ) and the basic polymerase 2 (PB2). In particular, the invention provides defective influenza virus particles having seven different influenza nucleic acid segments and lacking an influenza nucleic acid segment essentially encoding acidic polymerase. Furthermore, the invention provides use of a composition comprising a defective influenza virus particle according to the invention for the production of a pharmaceutical composition directed at generating immunological protection against infection of a subject with an influenza virus, and provides a method for generating immunological protection against infection of a subject with an influenza virus comprising providing a subject in need thereof with a composition comprising such defective influenza virus particle.
(FR) L'invention a trait au virus de la grippe et à la vaccination antigrippale. Elle concerne une particule du virus de la grippe conditionnellement défectif qui comporte sept segments d'acide nucléique de la grippe différents. L'invention concerne aussi une particule du virus de la grippe conditionnellement défectif à laquelle il manque un segment d'acide nucléique de la grippe, sélectionné dans le groupe des segments codant essentiellement pour la polymérase acide (PA), la polymérase 1 basique (PB1 ) et la polymérase 2 basique (PB2). Elle concerne en particulier des particules du virus de la grippe conditionnellement défectif qui comportent sept segments d'acide nucléique de la grippe différents et auxquelles il manque un segment d'acide nucléique de la grippe codant essentiellement pour la polymérase acide. L'invention concerne de plus l'utilisation d'une composition comprenant une particule du virus de la grippe défectif de l'invention en vue de produire une composition pharmaceutique induisant chez un sujet une protection immunologique contre l'infection par le virus de la grippe; et un procédé visant à induire chez un sujet une protection immunologique contre l'infection par le virus de la grippe, qui consiste à fournir à un sujet nécessitant un tel traitement une composition comprenant la particule du virus de la grippe défectif.
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