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1. WO2006049404 - SPHINGOSINE KINASE ACTIVATOR AND SKIN DISEASE TREATING AGENT COMPRISING THE SAME

Publication Number WO/2006/049404
Publication Date 11.05.2006
International Application No. PCT/KR2005/003586
International Filing Date 27.10.2005
IPC
A61K 31/164 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
164of a carboxylic acid with an aminoalcohol, e.g. ceramides
CPC
A61K 8/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
A61Q 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
08Anti-ageing preparations
C07C 235/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
08having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
C07C 235/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
70having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
72with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
74of a saturated carbon skeleton
Applicants
  • NEOPHARM CO., LTD. [KR]/[KR] (AllExceptUS)
  • PARK, Byeong-Deog [KR]/[KR] (UsOnly)
  • YOUM, Jong-Kyung [KR]/[KR] (UsOnly)
  • GWAK, Hyung-Sub [KR]/[KR] (UsOnly)
  • KWON, Mi-Jong [KR]/[KR] (UsOnly)
  • LEE, Yong-Moon [KR]/[KR] (UsOnly)
  • KIM, Yoo-Hun [KR]/[KR] (UsOnly)
  • KIM, Hwan-Mook [KR]/[KR] (UsOnly)
  • PARK, Song-Kyu [KR]/[KR] (UsOnly)
  • LEE, Ki-Ho [KR]/[KR] (UsOnly)
  • LEE, Chang-Woo [KR]/[KR] (UsOnly)
  • LEE, Myong-Lyoll [KR]/[KR] (UsOnly)
Inventors
  • PARK, Byeong-Deog
  • YOUM, Jong-Kyung
  • GWAK, Hyung-Sub
  • KWON, Mi-Jong
  • LEE, Yong-Moon
  • KIM, Yoo-Hun
  • KIM, Hwan-Mook
  • PARK, Song-Kyu
  • LEE, Ki-Ho
  • LEE, Chang-Woo
  • LEE, Myong-Lyoll
Agents
  • KWON, Hyuk-Cheol
Priority Data
10-2004-008855303.11.2004KR
10-2005-009659113.10.2005KR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SPHINGOSINE KINASE ACTIVATOR AND SKIN DISEASE TREATING AGENT COMPRISING THE SAME
(FR) ACTIVATEUR DE LA SPHINGOSINE KINASE ET AGENT DE TRAITEMENT DE MALADIES CUTANEES COMPRENANT CELUI-CI
Abstract
(EN) Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids. Therefore, the sphingosine kinase activator is useful for a skin disease treating agent for treating skin wounds, wrinkles, atopic dermatitis, eczema, psoriasis, or skin atrophy caused by side effects of local application steroids.
(FR) Composé céramide non naturel utilisé efficacement dans un activateur de la sphingosine kinase et de ce fait, pour un agent de traitement de maladies cutanées. L'activateur de la sphingosine kinase améliore la production de sphingosine-1-phosphate arborant plusieurs activités physiologiques. Les activités physiologiques, à savoir la surveillance de la multiplication de la différenciation de kératinocytes, la multiplication de fibroblastes et de la synthèse de collagène, ce qui se traduit par le traitement de blessures, la récupération de fonctions de la peau suite à une lésion dans la dermatite atopique et le psoriasis; inhibition des rides et de l'irritation de la peau causées par les rayons ultraviolets, amélioration des rides et inhibition du vieillissement de la peau; et réduction de l'atrophie de la peau, qui est un effet secondaire typique des stéroïdes à application locale. Par conséquent, l'activateur de sphingosine kinase est utilisé avec un agent de traitement de maladies cutanées en vue du traitement des blessures, des rides, de la dermatite atopique, de l'eczéma, du psoriasis ou de l'atrophie de la peau qui sont causées par les effets secondaires de stéroïdes à application locale.
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