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1. WO2006049300 - METHOD OF DETECTING PLATELET THROMBOSIS OR ORGAN INJURY

Publication Number WO/2006/049300
Publication Date 11.05.2006
International Application No. PCT/JP2005/020451
International Filing Date 08.11.2005
IPC
C12Q 1/37 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
37involving peptidase or proteinase
G01N 33/573 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
CPC
C12Q 1/56
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
56involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
G01N 2333/96463
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
964derived from animal tissue
96425from mammals
96427in general
9643with EC number
96433Serine endopeptidases (3.4.21)
96441with definite EC number
96463Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
G01N 2333/966
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
966Elastase
G01N 2333/968
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
968Plasmin, i.e. fibrinolysin
G01N 2333/974
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
974Thrombin
G01N 2800/226
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
22Haematology
226Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
Applicants
  • 株式会社三菱化学ヤトロン MITSUBISHI KAGAKU IATRON, INC. [JP]/[JP] (AllExceptUS)
  • 小野 智子 ONO, Tomoko [JP]/[JP] (UsOnly)
Inventors
  • 小野 智子 ONO, Tomoko
Agents
  • 森田 憲一 MORITA, Kenichi
Priority Data
2004-32377008.11.2004JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD OF DETECTING PLATELET THROMBOSIS OR ORGAN INJURY
(FR) MÉTHODE DE DÉTECTION DE THROMBOSE DE PLAQUETTES SANGUINES OU DE DÉGÂTS À UN ORGANE
(JA) 血小板血栓症又は臓器障害の検出方法
Abstract
(EN) A method of detecting platelet thrombosis or organ injury in a patient suffering from disseminated intravascular coagulation (DIC) syndrome or systemic inflammatory response syndrome (SIRS) by analyzing a von Willebrand factor-degrading enzyme and/or a degrading factor thereof. A kit for detecting platelet thrombosis or organ injury in a patient suffering from DIC or SIRS which contains an antibody capable of binding specifically to a von Willebrand factor-degrading enzyme or its fragment and an antibody capable of binding specifically to a degrading factor of a von Willebrand factor-degrading enzyme or its fragment.
(FR) La présente invention a pour objet une méthode de détection de thromboses dues à des plaquettes sanguines ou de dégâts à un organe chez un patient souffrant du syndrome de coagulation intravasculaire disséminée (CIVD) ou du syndrome de réponse inflammatoire systémique (SRIS) en analysant une enzyme dégradant le facteur de von Willebrand et/ou un facteur dégradé issu de ce dernier. La présente invention a également pour objet un dispositif de détection de thromboses dues à des plaquettes sanguines ou de dégâts à un organe chez un patient souffrant de CIVD ou de SRIS. Ledit dispositif contient un anticorps capable de se lier de façon spécifique à une enzyme dégradant le facteur de von Willebrand ou un résidu de ce dernier, ainsi qu’un anticorps capable de se lier de façon spécifique à un facteur dégradé issu d'une enzyme dégradant le facteur de von Willebrand ou d’un résidu de ce dernier.
(JA)  フォンヴィルブランド因子分解酵素及び/又はその分解因子を分析する、播種性血管内凝固症候群(DIC)又は全身性炎症反応症候群(SIRS)患者における血小板血栓症又は臓器障害を検出する方法を開示する。フォンヴィルブランド因子分解酵素に特異的に結合する抗体又はその断片、及び/又はフォンヴィルブランド因子分解酵素の分解因子に特異的に結合する抗体又はその断片を含む、DIC又はSIRS患者における血小板血栓症又は臓器障害の検出用キットを開示する。
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