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1. WO2006046690 - COMPOSITION FOR ORAL CAVITY

Publication Number WO/2006/046690
Publication Date 04.05.2006
International Application No. PCT/JP2005/019872
International Filing Date 28.10.2005
IPC
A61K 8/49 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 31/401 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401Proline; Derivatives thereof, e.g. captopril
A61P 1/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61Q 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastes; Mouth rinses
C07D 207/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
A61K 31/401
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401Proline; Derivatives thereof, e.g. captopril
A61K 8/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61Q 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
C07D 207/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants
  • 協和▲醗▼酵工業株式会社 KYOWA HAKKO KOGYO CO., LTD. [JP]/[JP] (AllExceptUS)
  • 島田 健次郎 SHIMADA, Kenjiro (UsOnly)
  • 高橋 徹 TAKAHASHI, Toru (UsOnly)
Inventors
  • 島田 健次郎 SHIMADA, Kenjiro
  • 高橋 徹 TAKAHASHI, Toru
Priority Data
2004-31326228.10.2004JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPOSITION FOR ORAL CAVITY
(FR) PRÉPARATION POUR CAVITÉ ORALE
(JA) 口腔用組成物
Abstract
(EN) A composition for the oral cavity which is effective in the prevention or treatment of periodontal diseases such as gingivitis, paradentitis, and alveolar pyorrhea. The composition for the oral cavity contains an N-acylated derivative of hydroxyproline, such as an N-acetyl derivative, N-propionyl derivative, or N-butyryl or N-isobutyryl derivative, or a salt of the derivative. The composition can be provided as a toothpaste, mouthwash, gingival-massaging cream, etc. which are effective in the prevention or treatment of periodontal diseases.
(FR) La présente invention a pour objet une préparation pour cavité orale qui permet le traitement prophylactique ou thérapeutique efficace de parondopathies telles que la gingivite, la parodontite, et la pyorrhée alvéolo-dentaire. Ladite préparation pour cavité orale contient un dérivé N-acylé de l’hydroxyproline, tel qu'un dérivé N-acétyle, N-propionyle, N-butyryle ou N-isobutyryle, ou un sel dudit dérivé. Ladite préparation peut être administrée sous forme de dentifrice, de bain de bouche, de crème de massage gingival, etc., ces produits étant efficaces dans le traitement prophylactique ou thérapeutique des parondopathies.
(JA)  歯肉炎、歯周炎、歯槽膿漏等の歯周病の予防または治療に有効な口腔用組成物を提供する。  本発明によれば、N-アセチル化誘導体、N-プロピオニル化誘導体、N-ブチリル化誘導体またはイソブチリル化誘導体等のヒドロキシプロリンのN-アシル化誘導体またはその塩を含有する、歯周病の予防または治療に有効な、歯磨剤、マウスウオッシュ、歯肉マッサージ用クリーム等の口腔用組成物を提供することができる。
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