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1. (WO2006046123) CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/046123 International Application No.: PCT/IB2005/003213
Publication Date: 04.05.2006 International Filing Date: 27.10.2005
Chapter 2 Demand Filed: 28.08.2006
IPC:
C07J 43/00 (2006.01) ,C07D 413/12 (2006.01) ,C07D 267/00 (2006.01) ,A61K 31/58 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
43
Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
267
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58
containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
TOMASKOVIC, Linda [HR/HR]; HR (UsOnly)
MARKOVIC, Stribor [HR/HR]; HR (UsOnly)
POLJAK, Visnja [HR/HR]; HR (UsOnly)
SIJAN, Gordana [HR/HR]; HR (UsOnly)
SELMANI, Selvira [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz baruna Filopovica 29 10000 Zagreb, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MESIC, Milan; HR
TOMASKOVIC, Linda; HR
MARKOVIC, Stribor; HR
POLJAK, Visnja; HR
SIJAN, Gordana; HR
SELMANI, Selvira; HR
Agent:
LUDWIG, Peter, S.; Darby & Darby P.C. P.O. Box 5257 New York, NY 10150-5257, US
Priority Data:
60/623,15427.10.2004US
Title (EN) CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY
(FR) CONJUGUES A ACTIVITE ANTI-INFLAMMATOIRE
Abstract:
(EN) The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: Z represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.
(FR) Nouveaux composés représentés par la formule (I) dans laquelle M représente une sous-unité de macrolide de la sous-structure VIII: L représente la chaîne de la sous-structure IX ou XIII: Z représente la sous-unité stéroïde ou non stéroïde dérivée de médicaments stéroïdes ou non stéroïdes (NSAID) à activité anti-inflammatoire. Sels pharmaceutiquement acceptables et solvates de ces composés préparés destinés à transformer les intermédiaires pour leur préparation et à améliore l'action thérapeutique et l'utilisation de ceux-ci dans le traitement de maladies et d'états inflammatoires chez les humains et les animaux.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)