Processing

Please wait...

Settings

Settings

Goto Application

1. WO2006045056 - FLAVONOID COMPOSITION FOR TREATING ORAL DISEASES

Publication Number WO/2006/045056
Publication Date 27.04.2006
International Application No. PCT/US2005/037936
International Filing Date 19.10.2005
IPC
A61K 31/35 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
A61K 9/68 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
68chewing gum type
A61K 8/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
A61K 8/97 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
96containing materials, or derivatives thereof, of undetermined constitution
97from algae, fungi, lichens or plants; from derivatives thereof
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
CPC
A61K 2800/782
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
74Biological properties of particular ingredients
78Enzyme modulators, e.g. Enzyme agonists
782Enzyme inhibitors; Enzyme antagonists
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/553
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
553having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 36/11
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
11Pteridophyta or Filicophyta (ferns)
Applicants
  • UNIGEN PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • JIA, Qi [US]/[US] (UsOnly)
  • ZHAO, Yuan [US]/[US] (UsOnly)
Inventors
  • JIA, Qi
  • ZHAO, Yuan
Agents
  • SWANSON AND BRATSCHUN LLC
Priority Data
60/620,16319.10.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLAVONOID COMPOSITION FOR TREATING ORAL DISEASES
(FR) PREPARATION D'INHIBITEURS DE SYSTEMES EICOSANOIDES ET DE SYSTEMES CYTOKINES DOUBLES DESTINEE A LA PREVENTION ET AU TRAITEMENT DES MALADIES ET DES AFFECTIONS BUCCO-DENTAIRES
Abstract
(EN)
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).
(FR)
L'invention concerne une nouvelle composition de matière contenant un mélange de deux catégories de composés, des flavanes et des flavonoïdes à cycle B libre, destinés à la prévention et au traitement de maladies et d'affections associées à la bouche, aux gencives et aux dents. Cette composition inhibe simultanément l'activité enzymatique de la cyclooxygénase (COS) et de la lipoxygénase (LOX) et réduit la production de cytokines au niveau de l'ARNm dans des cellules et des tissus parodontaux normaux, vieux et endommagés. L'invention concerne également une méthode de prévention et de traitement de maladies et d'affections de la bouche, des gencives et des dents. Cette méthode de prévention et de traitement consiste à administrer à un patient une quantité thérapeutiquement efficace d'une composition contenant un mélange de flavanes et de flavonoïdes à cycle B libre, synthétisés et/ou isolés à partir d'une plante unique ou de plantes multiples, de préférence dans le genre Scutellaria, Oroxylum, Acacia ou Uncaria, ainsi que des excipients pharmaceutiquement et/ou cosmétiquement acceptables. L'invention concerne enfin une méthode de prévention et de traitement des maladies et des affections de la bouche, des gencives ou des dents, entre autres les maladies parodontales, telles que la gingivite, la parodontite, la pulpite, les affections parodontales causées par l'implantation physique de prothèses buccales, les traumatismes, les blessures, le bruxisme, les processus néoplasiques et autres processus dégénératifs; l'albe, les pellicules, la plaque dentaire, les calculs et les taches. L'utilisation de la composition selon l'invention permet de maintenir une production de salive et un pH optimaux, de réduire au minimum la croissance bactérienne, de réduire la formation de pellicules et de plaque, d'inhiber la décalcification des dents et les caries dentaires, de promouvoir la reminéralisation, ce qui produit des gencives saines, de blanchir les dents, de maintenir une bonne hygiène buccale, et de réduire la mauvaise haleine (halitose).
Latest bibliographic data on file with the International Bureau