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1. WO2006044732 - 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

Publication Number WO/2006/044732
Publication Date 27.04.2006
International Application No. PCT/US2005/037148
International Filing Date 14.10.2005
Chapter 2 Demand Filed 14.08.2006
IPC
C07D 239/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
C07D 409/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 413/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 403/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 405/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
A61K 31/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
04Antipruritics
Applicants
  • AVENTIS PHARMACEUTICALS INC. [US]/[US] (AllExceptUS)
  • LIM, Sungtaek [KR]/[US] (UsOnly)
  • HARRIS, Keith, John [GB]/[US] (UsOnly)
  • STEFANY, David [US]/[US] (UsOnly)
  • GARDNER, Charles, J. [US]/[US] (UsOnly)
  • CAO, Bin [CN]/[US] (UsOnly)
  • BOFFEY, Ray [GB]/[GB] (UsOnly)
  • GILLESPY, Timothy, A. [US]/[US] (UsOnly)
  • AGUIAR, Joacy, C. [BR]/[US] (UsOnly)
  • HUNT, Hazel, J. [GB]/[GB] (UsOnly)
  • DECHAUX, Elsa, A. [FR]/[GB] (UsOnly)
Inventors
  • LIM, Sungtaek
  • HARRIS, Keith, John
  • STEFANY, David
  • GARDNER, Charles, J.
  • CAO, Bin
  • BOFFEY, Ray
  • GILLESPY, Timothy, A.
  • AGUIAR, Joacy, C.
  • HUNT, Hazel, J.
  • DECHAUX, Elsa, A.
Agents
  • BOLCSAK, James, W.
Priority Data
60/619,27215.10.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
(FR) AMINO-PYRIDIMIDINE 2, 6-SUBSTITUEE-4-MONOSUBSTITUEE EN TANT QU'ANTAGONISTES DE RECEPTEUR DE LA PROSTAGLANDINE D2
Abstract
(EN) The present invention is directed a compound of Formula (I) as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, discorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).
(FR) La présente invention a trait à un composé de formule (I) dans laquelle: Cy1, Cy2, L1, L2 et R1 sont tels que définis dans la description, à une composition pharmaceutique comprenant une quantité pharmaceutiquement efficace d'un ou de plusieurs composés de formule (I) en mélange avec un support pharmaceutiquement acceptable, et à un procédé de traitement d'un patient souffrant d'un trouble médié par la PGD2 comprenant, mais de manière non limitée, une maladie allergique (telle que la rhinite allergique, la conjonctivite allergique, la dermatite atopique, l'asthme et l'allergie alimentaire), la mastocytose systémique, des troubles accompagnés d'activation des mastocytes, le choc anaphylactique, la bronchoconstriction, la bronchite, l'urticaire, l'eczéma, les maladies accompagnées de démangeaison (telles que la dermatite atopique et l'urticaire), des maladies (telles que la cataracte, le décollement de la rétine, l'inflammation, l'infection et les troubles du sommeil) qui sont générées de manière secondaire conséquentes à un comportement accompagné de démangeaison (telles que griffures et battade), l'inflammation, les maladies obstructives respiratoires, la lésion ischémique au retour de la perfusion, l'accident vasculaire cérébral, la polyarthrite rhumatoïde chronique, la pleurésie, la colite ulcéreuse et analogues par l'administration au dit patient d'une quantité pharmaceutiquement efficace d'un composé de formule (I).
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