Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2006044531) ANTISENSE MODULATION OF PTP1B EXPRESSION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2006/044531 International Application No.: PCT/US2005/036813
Publication Date: 27.04.2006 International Filing Date: 13.10.2005
IPC:
A61K 31/7105 (2006.01) ,A61K 31/7125 (2006.01) ,A61K 31/64 (2006.01) ,A61K 31/155 (2006.01) ,A61K 31/425 (2006.01) ,A61K 31/70 (2006.01) ,A61K 38/28 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7125
Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
64
Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
Applicants:
ISIS PARMACEUTICALS, INC. [US/US]; 1896 Rutherford Road Carlsbad, Califonia, US (AllExceptUS)
BHANOT, Sanjay [CA/US]; US (UsOnly)
MONIA, Brett, P. [US/US]; US (UsOnly)
GEARY, Richard, S. [US/US]; US (UsOnly)
KJEMS, Lise, Lunt [DK/US]; US (UsOnly)
Inventors:
BHANOT, Sanjay; US
MONIA, Brett, P.; US
GEARY, Richard, S.; US
KJEMS, Lise, Lunt; US
Agent:
CAROLYN, Elmore ; Elmore Craig, and Vanstone 209 Main Street Chelmsford, MA 01863, US
Priority Data:
60/618,38413.10.2004US
60/653,16514.02.2005US
60/665,55524.03.2005US
60/688,98409.06.2005US
Title (EN) ANTISENSE MODULATION OF PTP1B EXPRESSION
(FR) MODULATION ANTISENS DE L'EXPRESSION DE PTP1B
Abstract:
(EN) Compositions and methods are provided for decreasing blood glucose levels in an animal or for preventing or delaying the onset of a rise in blood glucose levels in an animal, comprising administering to said animal an antisense inhibitor of PTP1B expression in combination with at least one glucose-lowering drug. The present invention is also directed to compositions and methods for improving insulin sensitivity in an animal or for preventing or delaying the onset of insulin resistance in an animal. Also provided are compositions and methods for treating or preventing a metabolic condition in an animal. The metabolic condition may be, e.g., diabetes or obesity.
(FR) L'invention porte sur des compositions et des procédés de diminution des niveaux de glycémie chez un animal ou de prévention et de temporisation du déclenchement de l'augmentation des niveaux de glycémie chez un animal, consistant à administrer à l'animal un inhibiteur antisens de l'expression de PTP1B en combinaison avec au moins un médicament de diminution de glucose. Cette invention concerne également des compositions et des procédés d'amélioration de la sensibilité à l'insuline chez un animal ou de prévention et de temporisation du déclenchement de la résistance à l'insuline chez un animal. Elle porte aussi sur des compositions et des procédés de traitement ou de prévention d'une condition métabolique chez un animal. Cette condition métabolique peut être, par exemple, le diabète ou l'obésité.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1807093JP2008515993US20090036355CA2582464AU2005295756