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1. WO2006042156 - MODULATION OF REPLICATIVE FITNESS BY USING LESS FREQUENTLY USED SYNONYMOUS CODONS

Publication Number WO/2006/042156
Publication Date 20.04.2006
International Application No. PCT/US2005/036241
International Filing Date 07.10.2005
IPC
C12N 5/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
CPC
A61K 2039/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
522avirulent or attenuated
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/0258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
025Enterobacteriales, e.g. Enterobacter
0258Escherichia
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 14/245
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
24from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245Escherichia (G)
Applicants
  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS represneted by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION [US]/[US] (AllExceptUS)
  • KEW, Olen, M. [US]/[US] (UsOnly)
  • BURNS, Cara, C. [US]/[US] (UsOnly)
  • SHAW, Jing [CN]/[US] (UsOnly)
  • CAMPAGNOLI, Raymond [US]/[US] (UsOnly)
  • QUAY, Jacqueline [US]/[US] (UsOnly)
Inventors
  • KEW, Olen, M.
  • BURNS, Cara, C.
  • SHAW, Jing
  • CAMPAGNOLI, Raymond
  • QUAY, Jacqueline
Agents
  • RYBAK, Sheree, L.
Priority Data
60/617,54508.10.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODULATION OF REPLICATIVE FITNESS BY USING LESS FREQUENTLY USED SYNONYMOUS CODONS
(FR) MODULATION DE LA VALEUR D'ADAPTATION REPLICATIVE PAR DESOPTIMISATION DE CODONS SYNONYMES
Abstract
(EN)
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
(FR)
L'invention concerne des méthodes de production d'un agent pathogène avec une valeur d'adaptation réplicative réduite, ainsi que des agents pathogènes atténués produits au moyen de ces méthodes. Dans des exemples spécifiques, la méthode consiste à désoptimiser au moins un codon dans une séquence de codage, ce qui permet de diminuer la valeur d'adaptation réplicative de l'agent pathogène. Cette invention a aussi trait à des méthodes d'utilisation des agents pathogènes atténués en tant que compositions immunogènes.
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