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1. WO2006041934 - METHODS AND COMPOSITIONS FOR IMPROVING RECOMBINANT PROTEIN PRODUCTION

Publication Number WO/2006/041934
Publication Date 20.04.2006
International Application No. PCT/US2005/035854
International Filing Date 05.10.2005
IPC
A61K 31/70 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
CPC
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
C07K 2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
Applicants
  • NEURALAB LIMITED [--]/[--] (AllExceptUS)
  • WYETH [US]/[US] (AllExceptUS)
  • SINACORE, Martin [US]/[US] (UsOnly)
  • ROUSE, Jason [US]/[US] (UsOnly)
Inventors
  • SINACORE, Martin
  • ROUSE, Jason
Agents
  • MANDRAGOURAS, Amy, E.
Priority Data
60/616,47405.10.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR IMPROVING RECOMBINANT PROTEIN PRODUCTION
(FR) PROCEDES ET COMPOSITIONS PERMETTANT D'AMELIORER LA FABRICATION DE PROTEINES RECOMBINANTES
Abstract
(EN)
Nucleic acid molecules modified to enhance recombinant protein expression, e.g., that of A&bgr; peptide binding antibodies, and/or to reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing A&bgr; peptide binding antibodies devoid of mis-spliced and/or intron read-through by-products by expression of such nucleic acid molecules under cell culture conditions suitable for recombinant A&bgr; peptide binding antibody expression.
(FR)
L'invention porte sur des molécules d'acide nucléique modifiées afin d'améliorer l'expression de protéines recombinantes, par exemple celle des anticorps de liaison du peptide Aß, et/ou afin de réduire ou d'éliminer des sous-produits mal épissés et/ou à transcription intronique. Cette invention concerne des procédés des fabrication d'anticorps de liaison du peptide Aß dépourvus de sous-produits mal épissés et/ou à transcription intronique par expression de ces molécules d'acide nucléique dans des conditions de culture cellulaire qui conviennent à l'expression de l'anticorps de liaison du peptide Aß.
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