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1. WO2006039716 - METHODS OF DETERMINING PRECISE HERG INTERACTIONS BY MUTAGENESIS

Publication Number WO/2006/039716
Publication Date 13.04.2006
International Application No. PCT/US2005/035870
International Filing Date 03.10.2005
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
C12N 15/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
CPC
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
G01N 2500/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
G01N 33/6872
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Applicants
  • NEURION PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • DOUGHERTY, Dennis, A. [US]/[US] (UsOnly)
  • LESTER, Henry, A. [US]/[US] (UsOnly)
  • NOWAK, Mark, W. [US]/[US] (UsOnly)
Inventors
  • DOUGHERTY, Dennis, A.
  • LESTER, Henry, A.
  • NOWAK, Mark, W.
Agents
  • MCPHERSON, Scott, E.
Priority Data
60/615,17301.10.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF DETERMINING PRECISE HERG INTERACTIONS BY MUTAGENESIS
(FR) PROCEDES PERMETTANT DE DETERMINER DES INTERACTIONS HERG PRECISES PAR MUTAGENESE
Abstract
(EN)
The present invention discloses methods of determining highly precise interactions between the HERG ion channel and various compounds. The methods of the present invention utilize modified HERG ion channels combined with heterologous in vivo expression in Xenopus oocytes and mammalian cells.
(FR)
La présente invention se rapporte à des procédés permettant de déterminer des interactions très précises entre le canal ionique HERG et divers composés. Les procédés selon l'invention font appel à des canaux ioniques HERG modifiés ainsi qu'à l'expression in vivo hétérologue dans des ovocytes de xénopus et des cellules de mammifères.
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