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1. WO2006037988 - NOVEL TECHNETIUM AND RHENIUM COMPLEXES, LIGANDS USED IN THEIR PREPARATION AND THEIR USE AS RADIOPHARMACEUTICALS

Publication Number WO/2006/037988
Publication Date 13.04.2006
International Application No. PCT/GB2005/003806
International Filing Date 04.10.2005
Chapter 2 Demand Filed 03.08.2006
IPC
A61K 51/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
C07F 13/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13Compounds containing elements of Groups 7 or 17 of the Periodic System
CPC
A61K 51/0476
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
0474complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
0476complexes from monodendate ligands, e.g. sestamibi
C07F 13/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13Compounds containing elements of Groups 7 or 17 of the Periodic System
Applicants
  • GE HEALTHCARE LIMITED [GB]/[GB] (AllExceptUS)
  • BHALLA, Rajiv [GB]/[GB] (UsOnly)
Inventors
  • BHALLA, Rajiv
Agents
  • CANNING, Lewis, Reuben
Priority Data
0421987.904.10.2004GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL TECHNETIUM AND RHENIUM COMPLEXES, LIGANDS USED IN THEIR PREPARATION AND THEIR USE AS RADIOPHARMACEUTICALS
(FR) NOUVEAUX COMPLEXES DE TECHNETIUM ET DE RHENIUM
Abstract
(EN)
Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radiopharmaceutical compositions comprising said complexes, kits for their preparation. The invention also relates to the us of 99mTc radiopharmaceuticals of the invention for SPECT imaging.
(FR)
L'invention porte sur de nouveaux complexes de technétium et de rhénium radioactifs renfermant des ligands tripodaux, en particulier sur des complexes Tc(I). L'invention porte sur de nouveaux ligands convenant à la formation des complexes de technétium et de rhénium, ainsi que sur des compositions radiopharmaceutiques renfermant lesdits complexes, et sur des kits servant à leur préparation. L'invention concerne également l'utilisation de produits radiopharmaceutiques 99mTc décrits dans l'invention se rapportant à la gammatomographie.
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