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1. WO2006037744 - DEGLYCOSYLATED AND DESIALIDATED LONG PENTRAXIN PTX3

Publication Number WO/2006/037744
Publication Date 13.04.2006
International Application No. PCT/EP2005/054860
International Filing Date 28.09.2005
IPC
C07K 14/475 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Applicants
  • SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A. [IT]/[IT] (AllExceptUS)
  • DE SANTIS, Rita [IT]/[IT] (UsOnly)
  • SALVATORI, Giovanni [IT]/[IT] (UsOnly)
  • CARMINATI, Paolo [IT]/[IT] (UsOnly)
  • INFORZATO, Antonio [IT]/[IT] (UsOnly)
Inventors
  • DE SANTIS, Rita
  • SALVATORI, Giovanni
  • CARMINATI, Paolo
  • INFORZATO, Antonio
Agents
  • SPADARO, Marco
Priority Data
RM 2004 A 00048908.10.2004IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEGLYCOSYLATED AND DESIALIDATED LONG PENTRAXIN PTX3
(FR) PENTRAXINE LONGUE PTX3 DEGLYCOSYLEE ET DESIALIDEE
Abstract
(EN)
Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.
(FR)
L'invention concerne une pentraxine longue PTX3 déglycosylée et une pentraxine longue PTX3 désialidée, des procédés d'élaboration correspondants, des compositions pharmacologiques contenant ces substances, et leur utilisation dans la préparation d'un médicament approprié au traitement de maladies pour lesquelles la pentraxine longue PTX est indiquée, en particulier les maladies infectieuses et inflammatoires et les troubles de la fertilité chez la femme. Ces protéines ont une activité thérapeutique supérieure à celle de la pentraxine glycosylée.
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