WO2006035673 NOVEL METHOD OF PROTECTING ISCHEMIC CARDIOPATHY

独立行政法人科学技術振興機構 JAPAN SCIENCE AND TECHNOLOGY AGENCY [JP]/[JP] (AllExceptUS)
大学共同利用機関法人自然科学研究機構 NATIONAL INSTITUTES OF NATURAL SCIENCES [JP]/[JP] (AllExceptUS)
岡田泰伸 OKADA, Yasunobu (UsOnly)
浦本裕美 URAMOTO, Hiromi (UsOnly)

Inventors

岡田泰伸 OKADA, Yasunobu
浦本裕美 URAMOTO, Hiromi

Agents

特許業務法人原謙三国際特許事務所 HARAKENZO WORLD PATENT & TRADEMARK

Priority Data

2004-281633

28.09.2004

Publication Language Japanese (JA)

Filing Language Japanese (JA)

Designated States

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Title

(EN) NOVEL METHOD OF PROTECTING ISCHEMIC CARDIOPATHY

(FR) NOUVELLE MÉTHODE DE PRÉVENTION DES CARDIOPATHIES ISCHÉMIQUES

(JA) 虚血性心臓傷害の新保護法

Abstract

(EN)

A method of preventing necrosis in myocardial cells occurring ischemia caused by blood flow injury or postischemic reperfusion; and a method of evaluating the necrosis in vitro and/or in vivo. A pharmaceutical composition for inhibiting cell death in ventricle muscle; a pharmaceutical composition for protecting cardiac muscle in a cardiac surgery and a transplant surgery; and a pharmaceutical composition for preventing a disease caused by necrosis.

(FR)

La présente invention décrit une méthode permettant d’empêcher une ischémie induisant la nécrose des cellules myocardiques, provoquée par un accident de circulation sanguine ou une reperfusion post-ischémique. La présente invention décrit également une méthode d’évaluation de la nécrose in vivo et/ou in vitro. La présente invention a en outre pour objet une préparation pharmaceutique permettant d’inhiber la mort cellulaire dans le muscle d'un ventricule, ainsi qu'une préparation pharmaceutique permettant de protéger le muscle cardiaque en cas d’intervention chirurgicale sur ledit muscle ou de transplantation, et une préparation pharmaceutique protégeant contre les maladies causées par une nécrose.

(JA)

　本発明は、血流障害に起因する虚血時または虚血後の再灌流時に生じる心筋細胞のネクローシスを防御する方法、ならびに当該ネクローシスをインビトロおよび／またはインビボで評価する方法に関するものである。さらに本発明は、心室筋の細胞死を抑制するための薬学的組成物、心臓の外科手術および移植手術において心筋を保護するための薬学的組成物およびネクローシスに起因する疾患を予防するための薬学的組成物に関するものである。

Also published as

EP1839675

JPWO2006035673

Latest bibliographic data on file with the International Bureau

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45	Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
21	Esters, e.g. nitroglycerine, selenocyanates
215	of carboxylic acids
22	of acyclic acids, e.g. pravastatin
23	of acids having a carboxyl group bound to a chain of seven or more carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non-condensed pyridines; Hydrogenated derivatives thereof
445	Non-condensed piperidines, e.g. piperocaine
4523	containing further heterocyclic ring systems
4545	containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7052	having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706	containing six-membered rings with nitrogen as a ring hetero atom
7064	containing condensed or non-condensed pyrimidines
7076	containing purines, e.g. adenosine, adenylic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9	Drugs for disorders of the cardiovascular system

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C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5	Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
06	Animal cells or tissues

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15	Medicinal preparations

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
G	TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
13	Operating tables; Auxiliary appliances therefor

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005	involving human or animal cells
5008	for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5082	Supracellular entities, e.g. tissue, organisms
5088	of vertebrates

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68	involving proteins, peptides or amino acids
6872	Intracellular protein regulatory factors and their receptors, e.g. including ion channels