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1. WO2006035673 - NOVEL METHOD OF PROTECTING ISCHEMIC CARDIOPATHY

Publication Number WO/2006/035673
Publication Date 06.04.2006
International Application No. PCT/JP2005/017494
International Filing Date 22.09.2005
Chapter 2 Demand Filed 13.07.2006
IPC
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 31/23 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
A61K 31/4545 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
4545containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/7076 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC
A61K 31/23
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
A61K 31/4545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
4545containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • 独立行政法人科学技術振興機構 JAPAN SCIENCE AND TECHNOLOGY AGENCY [JP]/[JP] (AllExceptUS)
  • 大学共同利用機関法人自然科学研究機構 NATIONAL INSTITUTES OF NATURAL SCIENCES [JP]/[JP] (AllExceptUS)
  • 岡田 泰伸 OKADA, Yasunobu (UsOnly)
  • 浦本 裕美 URAMOTO, Hiromi (UsOnly)
Inventors
  • 岡田 泰伸 OKADA, Yasunobu
  • 浦本 裕美 URAMOTO, Hiromi
Agents
  • 特許業務法人原謙三国際特許事務所 HARAKENZO WORLD PATENT & TRADEMARK
Priority Data
2004-28163328.09.2004JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL METHOD OF PROTECTING ISCHEMIC CARDIOPATHY
(FR) NOUVELLE MÉTHODE DE PRÉVENTION DES CARDIOPATHIES ISCHÉMIQUES
(JA) 虚血性心臓傷害の新保護法
Abstract
(EN)
A method of preventing necrosis in myocardial cells occurring ischemia caused by blood flow injury or postischemic reperfusion; and a method of evaluating the necrosis in vitro and/or in vivo. A pharmaceutical composition for inhibiting cell death in ventricle muscle; a pharmaceutical composition for protecting cardiac muscle in a cardiac surgery and a transplant surgery; and a pharmaceutical composition for preventing a disease caused by necrosis.
(FR)
La présente invention décrit une méthode permettant d’empêcher une ischémie induisant la nécrose des cellules myocardiques, provoquée par un accident de circulation sanguine ou une reperfusion post-ischémique. La présente invention décrit également une méthode d’évaluation de la nécrose in vivo et/ou in vitro. La présente invention a en outre pour objet une préparation pharmaceutique permettant d’inhiber la mort cellulaire dans le muscle d'un ventricule, ainsi qu'une préparation pharmaceutique permettant de protéger le muscle cardiaque en cas d’intervention chirurgicale sur ledit muscle ou de transplantation, et une préparation pharmaceutique protégeant contre les maladies causées par une nécrose.
(JA)
 本発明は、血流障害に起因する虚血時または虚血後の再灌流時に生じる心筋細胞のネクローシスを防御する方法、ならびに当該ネクローシスをインビトロおよび/またはインビボで評価する方法に関するものである。さらに本発明は、心室筋の細胞死を抑制するための薬学的組成物、心臓の外科手術および移植手術において心筋を保護するための薬学的組成物およびネクローシスに起因する疾患を予防するための薬学的組成物に関するものである。                                                                             
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