WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006035051) A BACTERIAL ATP SYNTHASE BINDING DOMAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/035051 International Application No.: PCT/EP2005/054893
Publication Date: 06.04.2006 International Filing Date: 28.09.2005
IPC:
C07K 14/35 (2006.01) ,C12N 15/31 (2006.01) ,C12N 15/52 (2006.01) ,G01N 33/50 (2006.01) ,A61K 31/00 (2006.01)
Applicants: ANDRIES, Koenraad, Jozef, Lodewijk, Marcel[BE/BE]; BE (UsOnly)
GÖHLMANN, Hinrich, Wilhelm, Helmut[DE/NL]; BE (UsOnly)
NEEFS, Jean-Marc, Edmond, Fernand, Marie[BE/BE]; BE (UsOnly)
VERHASSELT, Peter, Karel, Maria[BE/BE]; BE (UsOnly)
WINKLER, Johann[AT/BE]; BE (UsOnly)
DE JONGE, Marc, René[NL/NL]; BE (UsOnly)
KOYMANS, Lucien, Maria, Henricus[NL/BE]; BE (UsOnly)
JANSSEN PHARMACEUTICA N.V.[BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE (AllExceptUS)
Inventors: ANDRIES, Koenraad, Jozef, Lodewijk, Marcel; BE
GÖHLMANN, Hinrich, Wilhelm, Helmut; BE
NEEFS, Jean-Marc, Edmond, Fernand, Marie; BE
VERHASSELT, Peter, Karel, Maria; BE
WINKLER, Johann; BE
DE JONGE, Marc, René; BE
KOYMANS, Lucien, Maria, Henricus; BE
Common
Representative:
JANSSEN PHARMACEUTICA N.V.; Turnhoutseweg 30 B-2340 Beerse, BE
Priority Data:
04104720.028.09.2004EP
60/620,50020.10.2004US
Title (EN) A BACTERIAL ATP SYNTHASE BINDING DOMAIN
(FR) DOMAINE DE LIAISON D'ATP SYNTASE BACTERIENNE
Abstract:
(EN) This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.
(FR) L'invention concerne une protéine atpE mutante isolée et l'identification d'un domaine de liaison d'ATPase basé sur ladite protéine mutante. Elle concerne également des acides nucléiques, des vecteurs, des cellules hôtes, des compositions pharmaceutiques et des articles associés. Elle concerne, de plus, des méthodes servant à déterminer si un composé d'essai entre en interaction avec la protéine atpE, à savoir, avec le domaine de fixation d'ATPase, ainsi que des compositions pharmaceutiques contenant ledit composé d'essai, en particulier, sous forme d'agent antimicrobien, plus particulièrement, en tant qu'agent antimycobactérien, et encore plus particulièrement, en tant qu'agent servant à traiter la tuberculose chez un individu.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)