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Pub. No.:    WO/2006/020935    International Application No.:    PCT/US2005/028861
Publication Date: 23.02.2006 International Filing Date: 12.08.2005
A61K 39/395 (2006.01), C07K 16/00 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
LI, Li [CH/US]; (US) (For US Only).
KANTOR, Angela [US/US]; (US) (For US Only).
MACMILLAN, Shannon, B [US/US]; (US) (For US Only)
Inventors: LI, Li; (US).
KANTOR, Angela; (US).
MACMILLAN, Shannon, B; (US)
Agent: GELLER, Lisa, N.; Wilmer Cutler Pickering Hale and Dorr LLP, 60 State Street, Boston, MA 02109 (US)
Priority Data:
60/601,311 13.08.2004 US
Abstract: front page image
(EN)Formulations are described that are suitable for storage of proteins, such as antibodies, over a relatively broad range of protein concentrations, pH, and buffer types. Also described are methods of storing a protein and methods of identifying a suitable formulation for storage of a specific protein. In general, a formulation contains low to no surfactant, no to relatively low salt concentrations, and requires a relatively low buffer concentration.
(FR)La présente invention se rapporte à des préparations permettant de conserver des protéines, telles que des anticorps, avec une gamme relativement large de teneurs en protéines, de pH et de types de solutions tampons. L'invention a également trait à des procédés de conservation d'une protéine, et à des procédés d'identification d'une préparation permettant de conserver une protéine spécifique. En général, une préparation selon l'invention contient une quantité faible à nulle de tensioactif, une teneur en sel nulle à relativement faible, et nécessite une teneur en solution tampon relativement faible.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)