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Pub. No.:    WO/2006/020849    International Application No.:    PCT/US2005/028713
Publication Date: 23.02.2006 International Filing Date: 11.08.2005
C07K 14/54 (2006.01), C12N 15/24 (2006.01)
Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, INC. [US/US]; 330 Brookline Avenue, Boston, MA 02215 (US) (For All Designated States Except US).
F. HOFFMANN-LA ROCHE AG [CH/CH]; 124, Grenzacherstrasse, CH-4070 Basel (CH) (For All Designated States Except US).
ZHENG, Xin, Xiao [CN/US]; (US) (For US Only).
STROM, Terry, B. [US/US]; (US) (For US Only).
MOLL, Thomas [DE/US]; (US) (For US Only)
Inventors: ZHENG, Xin, Xiao; (US).
STROM, Terry, B.; (US).
MOLL, Thomas; (US)
Agent: CREWS, Lee, J., D.; Fish & Richardson P.C., 225 Franklin Street, Boston, MA 02110-2804 (US)
Priority Data:
60/601,042 11.08.2004 US
60/600,478 11.08.2004 US
Abstract: front page image
(EN)Mutant IL-15 polyp eptides and compositions including the polypeptides are described herein. In various embodiments, a mutant IL-15 polypeptide is joined to a heterologous polypeptide. Also described herein are uses of the mutant IL-15 polypeptides, e.g., in suppressing immune responses.
(FR)L'invention concerne des polypeptide d'IL-15 et des compositions comprenant ces polypeptides. Diverses formes de réalisation de l'invention comprennent un polypeptide d'IL-15 mutant fusionné avec un polypeptide hétérologue. L'invention porte également sur les utilisations de ces polypeptides d'IL-15 mutants, notamment pour la suppression des réponses immunitaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)