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1. (WO2006020684) METHODS OF REGULATING DIFFERENTIATION AND TREATING OF MULTIPLE MYELOMA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/020684    International Application No.:    PCT/US2005/028362
Publication Date: 23.02.2006 International Filing Date: 10.08.2005
IPC:
C12N 15/11 (2006.01), A61K 38/18 (2006.01), A61K 35/76 (2006.01), A61K 31/00 (2006.01), G01N 33/574 (2006.01), A61P 35/02 (2006.01)
Applicants: INSTITUTE FOR MULTIPLE MYELOMA AND BONE CANCER RESEARCH [US/US]; Suite 300, 9201 Sunset Boulevard, West Hollywood, California 90069 (US) (For All Designated States Except US).
BERENSON, James [US/US]; (US) (For US Only).
HAIMING, Chen [US/US]; (US) (For US Only).
GORDON, Melinda, S. [US/US]; (US) (For US Only)
Inventors: BERENSON, James; (US).
HAIMING, Chen; (US).
GORDON, Melinda, S.; (US)
Agent: LAHERTY, Carol, D.; Seed Intellectual Property Law Group, 701 Fifth Avenue, Suite 6300, Seattle, Washington 98104-7092 (US)
Priority Data:
60/600,132 10.08.2004 US
Title (EN) METHODS OF REGULATING DIFFERENTIATION AND TREATING OF MULTIPLE MYELOMA
(FR) PROCEDES POUR REGULER LA DIFFERENCIATION ET TRAITER LE MYELOME MULTIPLE
Abstract: front page image
(EN)The present invention provides methods of regulating cellular differentiation, including differentiation of stem cells and trans-differentiation of monocytes/macrophages using agonists or antagonists of pleiotrophin or a pleiotrophin receptor, as well as related methods of treating cancers associated with pleiotrophin-regulated differentiation and angiogenesis, including, e.g., multiple myeloma.
(FR)L'invention concerne des procédés pour réguler la différenciation cellulaire, y compris la différenciation de cellules souches et la transdifférenciation de monocytes/macrophages, au moyen d'agonistes ou d'antagonistes de pleiotrophine ou d'un récepteur de pleiotrophine. Cette invention se rapporte en outre à des procédés pour traiter des cancers associés à une différenciation régulée par la pleiotrophine et l'angiogenèse, y compris par ex. le myélome multiple.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)