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1. (WO2006020365) METHOD FOR PREVENTION OR TREATMENT OF INFLAMATORY DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/020365    International Application No.:    PCT/US2005/026312
Publication Date: 23.02.2006 International Filing Date: 25.07.2005
IPC:
A61K 9/127 (2006.01), A61K 9/50 (2006.01), A61K 9/51 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor, Oakland, CA 94607-5200 (US) (For All Designated States Except US).
FIRESTEIN, Gary, Steven [US/US]; (US) (For US Only).
BOYLE, David, Louis [US/US]; (US) (For US Only).
SORKIN, Linda, Sue [US/US]; (US) (For US Only)
Inventors: FIRESTEIN, Gary, Steven; (US).
BOYLE, David, Louis; (US).
SORKIN, Linda, Sue; (US)
Agent: STEIN, Michael, D.; Woodcock Washburn LLP, 2929 Arch Street - Suite 1200, Philadelphia, PA 19104-2891 (US)
Priority Data:
60/591,327 26.07.2004 US
60/606,580 01.09.2004 US
Title (EN) METHOD FOR PREVENTION OR TREATMENT OF INFLAMATORY DISEASE
(FR) METHODES PERMETTANT DE PREVENIR OU DE TRAITER UNE MALADIE INFLAMMATOIRE
Abstract: front page image
(EN)Methods are provided for prevention or treatment of inflammatory disease in a mammal by administering an inhibitor of mitogen activated (MAP) kinase system to the mammal in a therapeutic amount to the mammal in need thereof. The MAP kinase inhibitor is targeted to the central nervous system of the mammal. Methods are further provided for prevention or treatment of inflammatory disease in a mammal by administering an antagonist of TNF-&agr; to the mammal in a therapeutic amount to the mammal in need thereof. The TNF-&agr; antagonist is targeted to the central nervous system of the mammal.
(FR)La présente invention concerne des méthodes permettant de prévenir ou de traiter une maladie inflammatoire chez un mammifère par administration d'une quantité thérapeutique d'un inhibiteur de la MAP kinase au mammifère qui le nécessite. L'inhibiteur de la MAP kinase est destiné au système nerveux central du mammifère. Cette invention concerne également des méthodes permettant de prévenir ou de traiter une maladie inflammatoire chez un mammifère par administration d'une quantité thérapeutique d'un antagoniste de TNF-a mammifère qui le nécessite. L'antagoniste de TNF-a est destiné au système nerveux central du mammifère.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)