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Machine translation
1. (WO2006020060) IAP BINDING COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/020060    International Application No.:    PCT/US2005/025208
Publication Date: 23.02.2006 International Filing Date: 15.07.2005
IPC:
C07D 207/00 (2006.01), A61K 31/00 (2006.01), A61P 35/00 (2006.01)
Applicants: TETRALOGIC PHARMACEUTICALS CORPORATION [US/US]; 365 Phonixville Pike, malvern, PA 19355 (US) (For All Designated States Except US).
CONDON, Stephen, M. [US/US]; (US) (For US Only).
LAPORTE, Matthew, G. [US/US]; (US) (For US Only).
DENG, Yijun [CN/US]; (US) (For US Only).
RIPPIN, Susan, R. [US/US]; (US) (For US Only)
Inventors: CONDON, Stephen, M.; (US).
LAPORTE, Matthew, G.; (US).
DENG, Yijun; (US).
RIPPIN, Susan, R.; (US)
Agent: MILLER, Raymond, A.; Pepper Hamilton LLP, One Mellon Center, 50th Floor, 500 Grant Street, Pittsburgh, 15219 (US)
Priority Data:
60/588,050 15.07.2004 US
Title (EN) IAP BINDING COMPOUNDS
(FR) COMPOSES DE LIAISON AUX PROTEINES IAP
Abstract: front page image
(EN)IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
(FR)L'invention concerne des molécules de liaison aux protéines IAP et des compositions comprenant lesdites molécules. Ces molécules de liaison aux protéines IAP interagissent avec lesdites protéines IAP (protéines inhibitrices de l'apoptose) dans des cellules et peuvent être utilisées pour modifier l'apoptose dans les cellules traitées par lesdites molécules. Dans certains modes de réalisation, les composés de l'invention présentent une constante Kd inférieure à 0,1 micromole. L'invention concerne également des procédés d'utilisation desdites molécules de liaison aux protéines IAP à des fins thérapeutiques, diagnostiques, et d'analyse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)