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Pub. No.:    WO/2006/019940    International Application No.:    PCT/US2005/025038
Publication Date: 23.02.2006 International Filing Date: 14.07.2005
C07D 471/04 (2006.01), C07D 487/02 (2006.01), A61K 31/437 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000, Route 206 and ProvinceLine Road, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
FEVIG, John, M. [US/US]; (US) (For US Only).
FENG, Jianxin [CN/US]; (US) (For US Only).
AHMAD, Saleem [US/US]; (US) (For US Only)
Inventors: FEVIG, John, M.; (US).
FENG, Jianxin; (US).
AHMAD, Saleem; (US)
Agent: DUNCAN, Sammy, G.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/587,690 14.07.2004 US
11/180,861 13.07.2005 US
Abstract: front page image
(EN)The present application provides pyrrolo (oxo) isoquinolines as modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using such compounds and compositions.
(FR)L'invention porte sur des pyrrolo (oxo) isoquinolines à fonction de modulateurs des récepteurs de la sérotonine, et sur des méthodes de traitement au moyen ces composés et compositions de différentes maladies, états ou troubles, associés à la modulation des récepteurs de la sérotonine, tels que: les trouble du métabolisme dont non exclusivement l'obésité, le diabète et ses complications, l'athérosclérose, une mauvaise tolérance au glucose et la dyslipidémie; les maladies du SNC dont non exclusivement l'anxiété, la dépression, la névrose obsessionnelle, les troubles paniques, les psychoses, la schizophrénie, les troubles du sommeil, les troubles sexuels et les phobies sociales; la douleur céphalique; la migraine; et les troubles gastro-intestinaux.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)