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1. (WO2006018849) NON-INVASIVE PRENATAL GENETIC DIAGNOSIS USING TRANSCERVICAL CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/018849    International Application No.:    PCT/IL2005/000901
Publication Date: 23.02.2006 International Filing Date: 18.08.2005
IPC:
C12N 5/06 (2006.01), C12Q 1/68 (2006.01)
Applicants: MONALIZA MEDICAL LTD. [IL/IL]; 11 Hasadna Street, 43650 RaAnana (IL) (For All Designated States Except US).
FEJGIN, Moshe, D. [IL/IL]; (IL) (For US Only).
AMIEL, Aliza [IL/IL]; (IL) (For US Only).
LIBERMAN, Meytal [IL/IL]; (IL) (For US Only)
Inventors: FEJGIN, Moshe, D.; (IL).
AMIEL, Aliza; (IL).
LIBERMAN, Meytal; (IL)
Agent: G. E. EHRLICH (1995) LTD.; 11 Menachem Begin Street, 52 521 Ramat Gan (IL)
Priority Data:
10/921,899 20.08.2004 US
11/088,882 25.03.2005 US
Title (EN) NON-INVASIVE PRENATAL GENETIC DIAGNOSIS USING TRANSCERVICAL CELLS
(FR) DIAGNOSTIC GENETIQUE PRENATAL NON INVASIF FAISANT APPEL A DES CELLULES TRANSCERVICALES
Abstract: front page image
(EN) A non-invasive, risk-free method of prenatal diagnosis is provided. According to the method of the present invention cell specimens are subjected to molecular and morphological methods which allow trophoblast identification. Trophoblasts identified according to the teachings of the present invention can be further examined to thereby prenatally diagnosing a fetus. Also provided is a method of in situ chromosomal, DNA and/or RNA analysis of a prestained specimen by incubating the prestained specimen in ammonium hydroxide. Also provided is a method of identifying embryonic cells according to a nucleus/cytoplasm ratio of at least 0.3 and the presence of at least variably condensed chromatin.
(FR)L'invention concerne une méthode non invasive de diagnostic prénatal ne comportant pas de risques. Selon cette méthode, des échantillons cellulaires sont soumis à des méthodes moléculaires et morphologiques pour permettre l'identification de trophoblastes. Les trophoblastes identifiés selon l'invention peuvent ensuite être examinés pour un diagnostic prénatal de foetus. L'invention concerne également une méthode d'analyse d'ADN et/ou d'ARN chromosomique in situ d'un échantillon prémarqué consistant à faire incuber l'échantillon dans de l'hydroxyde d'ammonium. L'invention concerne une méthode pour identifier des cellules embryonnaires selon un rapport noyau/cytoplasme d'au moins 0,3; et la présence de chromatine au moins variablement condensée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)