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1. (WO2006018446) METHOD TO IMPROVE LACTOCOCCUS PRESERVATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/018446    International Application No.:    PCT/EP2005/054088
Publication Date: 23.02.2006 International Filing Date: 18.08.2005
IPC:
C12N 1/04 (2006.01)
Applicants: ACTOGENIX NV [BE/BE]; Technologiepark 4, B-9052 Zwijnaarde (BE) (For All Designated States Except US).
REMAUT, Erik [BE/BE]; (BE) (For US Only).
ISERENTANT, Dirk [BE/BE]; (BE) (For US Only)
Inventors: REMAUT, Erik; (BE).
ISERENTANT, Dirk; (BE)
Agent: BRANTS, Johan, Philippe; De Clercq Brants & Partners, Edgard Gevaertdreef 10a, B-9830 Sint-Martens-Latem (BE)
Priority Data:
04104001.5 20.08.2004 EP
05102856.1 12.04.2005 EP
Title (EN) METHOD TO IMPROVE LACTOCOCCUS PRESERVATION
(FR) PROCEDE POUR AMELIORER LA CONSERVATION DE LA BACTERIE LACTOCOCCUS
Abstract: front page image
(EN)The present invention relates to Lactococcus lactis strains with improved preservation characteristics, and improved acid and bile salt tolerance. More specifically, the invention relates to a L. lactis strain comprising a heterologous trehalose-6-phosphate synthase gene and/or a trehalose-6-phosphate phosphatase gene, resulting in an accumulation of trehalose in the cytoplasm and/or in the cytoplasmic membrane. It further relates to a L. lactis strain, whereby said trehalose accumulation results in an internal trehalose concentration of at least 10 mg per gram cells (ww).
(FR)Cette invention concerne des souches de Lactococcus lactis ayant des caractéristiques de conservation améliorées, et une meilleure tolérance aux acides et au sel biliaire. Cette invention concerne plus spécifiquement une souche de L. lactis comprenant un gène de tréhalose-6-phosphate synthase hétérologue et/ou un gène de tréhalose-6-phosphate phosphatase, entraînant l'accumulation de tréhalose dans le cytoplasme et/ou dans la membrane cytoplasmique. Cette invention concerne en outre une souche de L. lactis, pour laquelle l'accumulation de tréhalose entraîne une concentration de tréhalose interne égale à au moins 10 mg par gramme de cellules (en poids).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)