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1. (WO2006018284) COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/018284    International Application No.:    PCT/EP2005/008896
Publication Date: 23.02.2006 International Filing Date: 16.08.2005
IPC:
C07D 239/42 (2006.01), C07D 401/12 (2006.01), C07D 405/14 (2006.01), A61K 31/506 (2006.01), A61P 25/02 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
NOVARTIS PHARMA GMBH [AT/AT]; Brunner Strasse 59, A-1230 Vienna (AT) (AT only).
HART, Terance, William [GB/GB]; (GB) (For US Only).
HALLETT, Allan [GB/GB]; (GB) (For US Only).
YOKOKAWA, Fumiaki [JP/JP]; (JP) (For US Only).
HIRAO, Hajime [JP/JP]; (JP) (For US Only).
EHARA, Takeru [JP/JP]; (JP) (For US Only).
IWASAKI, Atsuko [JP/JP]; (JP) (For US Only).
SAKAKI, Junichi [JP/JP]; (JP) (For US Only).
MASUYA, Keiichi [JP/CH]; (CH) (For US Only).
KISHIDA, Masashi [JP/JP]; (JP) (For US Only).
IRIE, Osamu [JP/JP]; (JP) (For US Only)
Inventors: HART, Terance, William; (GB).
HALLETT, Allan; (GB).
YOKOKAWA, Fumiaki; (JP).
HIRAO, Hajime; (JP).
EHARA, Takeru; (JP).
IWASAKI, Atsuko; (JP).
SAKAKI, Junichi; (JP).
MASUYA, Keiichi; (CH).
KISHIDA, Masashi; (JP).
IRIE, Osamu; (JP)
Agent: DE WEERD, Peter; Novartis AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
0418353.9 17.08.2004 GB
Title (EN) COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS
(FR) COMPOSES ET COMPOSITIONS UTILISES COMME INHIBITEURS DE LA CATHEPSINE S
Abstract: front page image
(EN)The present invention relates to the use of a 2-cyanopyrimidine compound of the formula (I), wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and , where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.
(FR)L'invention concerne un composé de 2-cyanopyrimidine représenté par la formule (I), dans laquelle R1, R2, R3 et X sont tels que définis dans la spécification et les revendications, sous forme libre ou sous forme de sel, et lorsque c'est possible, sous forme tautomère, utilisé comme inhibiteur de l'activité de la cathepsine S.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)