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Machine translation
1. (WO2006018188) SUBSTITUTED HYDANTOINS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/018188 International Application No.: PCT/EP2005/008633
Publication Date: 23.02.2006 International Filing Date: 09.08.2005
Chapter 2 Demand Filed: 15.02.2006
IPC:
C07D 417/12 (2006.01) ,C07D 417/14 (2006.01) ,A61K 31/427 (2006.01)
Applicants: CHU, Xin-Jie[CN/US]; US (UsOnly)
FOTOUHI, Nader[FR/US]; US (UsOnly)
HUBY, Nicholas, John, Silvester[GB/US]; US (UsOnly)
KONG, Norman[CA/US]; US (UsOnly)
MCDERMOTT, Lee, Apostle[US/US]; US (UsOnly)
MOLITERNI, John, Anthony[US/US]; US (UsOnly)
ZHANG, Zhuming[CN/US]; US (UsOnly)
F. HOFFMANN-LA ROCHE AG[CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
Inventors: CHU, Xin-Jie; US
FOTOUHI, Nader; US
HUBY, Nicholas, John, Silvester; US
KONG, Norman; US
MCDERMOTT, Lee, Apostle; US
MOLITERNI, John, Anthony; US
ZHANG, Zhuming; US
Agent: KLEIN, Thomas; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
60/602,17517.08.2004US
60/682,99720.05.2005US
Title (EN) SUBSTITUTED HYDANTOINS
(FR) HYDANTOINES SUBSTITUEES
Abstract: front page image
(EN) The present invention relates to compounds of the formula (I), which are useful in treating diseases characterized by, the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
(FR) La présente invention a trait à des composés de formule (I), utiles dans le traitement de maladies caractérisées par l'hyperactivité de la protéine kinase activée par des agents mitogènes/la kinase régulée par un signal extracellulaire (MEK). Par conséquent, les composés sont utiles dans le traitement de maladies telles que le cancer, les troubles cognitifs et du système nerveux central et des maladies inflammatoires/auto-immunes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)