Search International and National Patent Collections

1. (WO2006017859) ASSAYS AND METHODS USING BIOMARKERS

Pub. No.:    WO/2006/017859    International Application No.:    PCT/US2005/029045
Publication Date: Fri Feb 17 00:59:59 CET 2006 International Filing Date: Thu Aug 04 01:59:59 CEST 2005
IPC: C12Q 1/68
Applicants: GENENTECH, INC.
WAGNER, Klaus W.
Inventors: WAGNER, Klaus W.
Title: ASSAYS AND METHODS USING BIOMARKERS
Abstract:
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.