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1. (WO2006017859) ASSAYS AND METHODS USING BIOMARKERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/017859 International Application No.: PCT/US2005/029045
Publication Date: 16.02.2006 International Filing Date: 03.08.2005
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: WAGNER, Klaus W.[DE/US]; US (UsOnly)
GENENTECH, INC.[US/US]; 1 DNA Way South San Francisco, California 94080-4990, US (AllExceptUS)
Inventors: WAGNER, Klaus W.; US
Agent: MARSCHANG, Diane L.; Genentech, Inc. MS 49 1 DNA Way South San Francisco, California 94080, US
Priority Data:
60/599,39306.08.2004US
Title (EN) ASSAYS AND METHODS USING BIOMARKERS
(FR) DOSAGES ET PROCEDES METTANT EN OEUVRE DES BIOMARQUEURS
Abstract:
(EN) Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.
(FR) La présente invention a trait à des procédés et des dosages d'examen de l'expression d'un ou de plusieurs biomarqueurs dans un prélèvement tissulaire ou cellulaire mammalien. Selon les procédés et dosages de l'invention, la détection de l'expression d'un ou de plusieurs tels biomarqueurs constitue une prévision ou une indication que le prélèvement tissulaire ou cellulaire va être sensible à des agents d'induction de l'apoptose tels que Apo2L/TRAIL et des anticorps agonistes anti-DR5. Certains biomarqueurs qui peuvent être observés comprennent des fucosyltransférases, notamment la fucosyltransférase 3 (FUT3) et/ou la fucosyltransférase 6 (FUT6), ainsi que des antigènes de sialyle Lewis A et/ou X. L'invention a également trait à des trousses et des articles de fabrication.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)