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Machine translation
1. (WO2006017852) PHARMACEUTICAL COMPOSITIONS FOR CONTROLLED RELEASE DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/017852    International Application No.:    PCT/US2005/028676
Publication Date: 16.02.2006 International Filing Date: 11.08.2005
IPC:
A61K 9/14 (2006.01), A61K 9/20 (2006.01), A61K 9/22 (2006.01), A61K 9/24 (2006.01), A61K 9/26 (2006.01), A61K 9/48 (2006.01), A61K 9/52 (2006.01), A61K 9/54 (2006.01)
Applicants: QUEST PHARMACEUTICAL SERVICES [US/US]; Three Innovation Way, Suite 240, Newark, DE 19711 (US) (For All Designated States Except US).
YUHUA, Li [US/US]; (US) (For US Only).
CHIEN, Benjamin [US/US]; (US) (For US Only)
Inventors: YUHUA, Li; (US).
CHIEN, Benjamin; (US)
Agent: CHENG, Kent, H.; Cohen, Pontani, Lieberman & Pavane, 551 Fifth Avenue, New York, NY 10176 (US)
Priority Data:
60/600,907 12.08.2004 US
Title (EN) PHARMACEUTICAL COMPOSITIONS FOR CONTROLLED RELEASE DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS
(FR) COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA LIBERATION PROGRESSIVE DE COMPOSES BIOACTIFS
Abstract: front page image
(EN)The present invention provides compositions and methods for the controlled release delivery of one or more biologically active compounds to a subject. Specifically, the invention provides for a pharmaceutical composition for the controlled release delivery of biologically active compounds to a subject comprising: a) a complex of a biologically active compound having at least one basic functional group and a polyanion derived from hexahydroxycyclohexane having at least two negatively charged functional groups; and b) a pharmaceutically acceptable carrier comprising a biodegradable, water-insoluble polymer. By complexing a biologically active compound with a polyanion, the tight, stable complex may be incorporated into a long­ acting dosage system having a more desired drug release curve over time than that is found in the prior art. The invention also provides the methods of making such compositions and the methods of use thereof.
(FR)L'invention concerne des compositions et des procédés permettant la libération progressive d'un ou de plusieurs composés bioactifs administrés à un sujet, et plus spécifiquement une composition pharmaceutique permettant la libération progressive de composés bioactifs administrés à un sujet, Cette composition comprend: a) un complexe d'un composé bioactif possédant au moins un groupe fonctionnel basique et un polyanion dérivé de l'hexahydroxycyclohexane, comprenant au moins deux groupes fonctionnels à charge négative; et b) un véhicule pharmaceutiquement acceptable comprenant un polymère biodégradable, insoluble dans l'eau. La complexion d'un composé bioactif avec un polyanion permet d'obtenir un complexe stable et dense qui peut être incorporé dans un système posologique à action prolongée présentant une courbe de libération de médicament préférable à celle des systèmes antérieurs. L'invention porte en outre sur la préparation de ces compositions et sur des méthodes d'utilisation de ces dernières.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)