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1. (WO2006017759) TUMOR ENDOTHELIAL MARKER-1 (TEM1) BINDING ANTIBODIES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/017759    International Application No.:    PCT/US2005/027938
Publication Date: 16.02.2006 International Filing Date: 05.08.2005
IPC:
A61K 39/395 (2006.01), C07K 16/30 (2006.01), G01N 33/543 (2006.01)
Applicants: KIRIN BREWERY CO., LTD. [JP/JP]; 10-1, Shinkawa 2-chome, Chuo-ku, Tokyo 104-8288 (JP) (For All Designated States Except US).
GENZYME CORPORATION [US/US]; 15 Pleasant Street Connector, Framingham, MA 01701 (US) (For All Designated States Except US).
TEICHER, Beverly [US/US]; (US) (For US Only).
ROBERTS, Bruce [CA/US]; (US) (For US Only).
KATAOKA, Shiro [JP/JP]; (JP) (For US Only).
TAHARA, Tomoyuki [JP/JP]; (JP) (For US Only).
HONMA, Nakayuki [JP/JP]; (JP) (For US Only)
Inventors: TEICHER, Beverly; (US).
ROBERTS, Bruce; (US).
KATAOKA, Shiro; (JP).
TAHARA, Tomoyuki; (JP).
HONMA, Nakayuki; (JP)
Agent: HILL, Laurie, L.; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA 92130-2040 (US)
Priority Data:
60/599,359 05.08.2004 US
Title (EN) TUMOR ENDOTHELIAL MARKER-1 (TEM1) BINDING ANTIBODIES AND USES THEREOF
(FR) ANTICORPS FIXANT LE MARQUEUR SPECIFIQUE DES CELLULES ENDOTHELIALES (TEM1) ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention relates to antibodies that bind tumor endothelial marker 1 (TEM1) and effectively inhibit angiogenesis, tumor growth, or both. Pharmaceutical compositions and uses thereof for the treatment of angiogenesis-associated diseases including cancer, polycystic kidney disease, diabetic retinopathy, age-related macular degenerations, rheumatoid arthritis, and psoriasis are also disclosed. Also disclosed are methods of identifying such antibodies by assessing (1) the inhibitory activity of candidate antibodies in proliferation and tube formation assays using endothelial cells, endothelial precursor cells and pericytes, and (2) the antibody-dependent cellular cytotoxic, phagocytosis, and complement-dependent cytotoxic activities of candidate antibodies.
(FR)L'invention concerne des anticorps qui fixent le marqueur 1 spécifique des cellules endothéliales (TEM1) et qui inhibent efficacement l'angiogenèse, la croissance tumorale ou les deux. Des compositions pharmaceutiques et leurs utilisations pour le traitement de maladies associées à l'angiogenèse, dont le cancer, la néphropathie polycystique, la rétinopathie diabétique, la dégénérescence maculaire liée à l'âge, la polyarthrite rhumatoïde et le psoriasis. L'invention porte également sur des méthodes d'identification desdits anticorps par l'évaluation (1) de l'activité inhibitrice d'anticorps candidats dans des essais de prolifération ou de formation de tubes au moyen de cellules endothéliales, de cellules précurseurs endothéliales et de péricytes, et (2) de la phagocytose cellulaire cytotoxique dépendant des anticorps, et des activités cytotoxiques dépendant du complément des anticorps candidats.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)