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1. (WO2006017578) PEPTIDE SEQUENCE FOR MODULATION OF DELTA PROTEIN KINASE C
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/017578    International Application No.:    PCT/US2005/027567
Publication Date: 16.02.2006 International Filing Date: 02.08.2005
IPC:
C12N 9/12 (2006.01), C07K 7/06 (2006.01), A61K 38/00 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Stanford, CA 94305 (US) (For All Designated States Except US).
MOCHLY-ROSEN, Daria [US/US]; (US) (For US Only).
KHEIFETS, Viktoria [US/US]; (US) (For US Only).
SCHECHTMAN, Deborah [BR/BR]; (BR) (For US Only).
INAGAKI, Koichi [JP/JP]; (US) (For US Only).
KIHARA, Yasuki [JP/JP]; (JP) (For US Only)
Inventors: MOCHLY-ROSEN, Daria; (US).
KHEIFETS, Viktoria; (US).
SCHECHTMAN, Deborah; (BR).
INAGAKI, Koichi; (US).
KIHARA, Yasuki; (JP)
Agent: MOHR, Judy, M.; Perkins Coie LLP, P.O. Box 2168, Manlo Park, CA 94026 (US)
Priority Data:
60/598,401 02.08.2004 US
60/598,458 02.08.2004 US
Title (EN) PEPTIDE SEQUENCE FOR MODULATION OF DELTA PROTEIN KINASE C
(FR) SEQUENCE PEPTIDIQUE POUR LA MODULATION DE LA PROTEINE KINASE C DELTA
Abstract: front page image
(EN)A peptide identified from the annexin V protein sequence and having the ability to modulate the activity of delta protein kinase C (PKC) is described. The peptide and variants thereof bind to delta PKC and are effective to regulate delta PKC mediated cellular responses. In particular the annexin V peptide is able to inhibit protein-protein interaction with delta PKC, blocking intracellular translocation of delta PKC. Inhibition of delta PKC translocation confers protection to tissue at risk of exposure to ischemia or hypoxia or to reperfusion injury.
(FR)L'invention concerne un peptide identifié à partir de la séquence protéique d'annexine V et possédant la capacité de moduler l'activité de la protéine kinase C delta (PKC). Ce peptide et des variants de celui-ci se lient à PKC delta et sont efficaces pour réguler des réponses cellulaires à médiation par PKC delta. Plus spécifiquement, le peptide d'annexine V est capable d'inhiber l'interaction protéine-protéine avec PKC delta, bloquant la translocation intracellulaire de PKC delta. L'inhibition de la translocation de PKC delta confère une protection à un tissu risquant d'être exposé à l'ischémie ou à l'hypoxie ou à une lésion de reperfusion.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)