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1. (WO2006017567) CUSTOMIZING STEM CELL-DERIVED CARDIOMYOCYTES FOR TRANSPLANTATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/017567 International Application No.: PCT/US2005/027550
Publication Date: 16.02.2006 International Filing Date: 02.08.2005
IPC:
A01N 63/00 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63
Biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, animals, e.g. nematodes, or substances produced by, or obtained from micro-organisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants: LI, Ronald, A.[CA/US]; US (UsOnly)
AKAR, Fadi, G.[US/US]; US (UsOnly)
CHO, Heecheol[CA/US]; US (UsOnly)
MARBAN, Eduardo[US/US]; US (UsOnly)
TOMASELLI, Gordon[US/US]; US (UsOnly)
THE JOHNS HOPKINS UNIVERSITY[US/US]; Johns Hopkins Technology Transfer 100 N. Charles Street 5th Floor Baltimore, MD 21201, US (AllExceptUS)
Inventors: LI, Ronald, A.; US
AKAR, Fadi, G.; US
CHO, Heecheol; US
MARBAN, Eduardo; US
TOMASELLI, Gordon; US
Agent: CORLESS, Peter, F. ; Edwards & Angell, LLP P.O. Box 55874 Boston, MA 02205, US
Priority Data:
60/598,17102.08.2004US
Title (EN) CUSTOMIZING STEM CELL-DERIVED CARDIOMYOCYTES FOR TRANSPLANTATION
(FR) ADAPTATION DE CARDIOMYOCYTES DERIVES DE CELLULES SOUCHES POUR TRANSPLANTATION
Abstract:
(EN) The present invention relates to methods of customizing the biological activity (e.g. rhythmic firing rate) of cardiomyocytes derived from pluripotent or multipotent stem cells, followed by transplantation to modify cardiac functions in vivo (e.g. to augment or attenuate the heart rate by modifying the cellular excitability of recipient cells).
(FR) La présente invention concerne des procédés d'adaptation de l'activité biologique (par exemple, de la fréquence de déclenchement rythmique) de cardiomyocytes dérivés de cellules souches pluripotentes ou multipotentes, suivie par une transplantation pour modifier les fonctions cardiaques in vivo (par exemple, pour augmenter ou diminuer la fréquence cardiaque en modifiant l'excitabilité cellulaire des cellules du receveur).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)