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Machine translation
1. (WO2006017542) SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/017542    International Application No.:    PCT/US2005/027500
Publication Date: 16.02.2006 International Filing Date: 03.08.2005
IPC:
C07D 209/02 (2006.01), C07D 221/22 (2006.01), A61K 31/403 (2006.01), A61K 31/46 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
WADDELL, Sherman, T. [US/US]; (US) (For US Only).
BALKOVEC, James, M. [US/US]; (US) (For US Only).
SANTORELLI, Gina, M. [US/US]; (US) (For US Only).
LEEMAN, Aaron, H. [US/US]; (US) (For US Only).
MALETIC, Milana [YU/US]; (US) (For US Only).
GU, Xin [CN/US]; (US) (For US Only)
Inventors: WADDELL, Sherman, T.; (US).
BALKOVEC, James, M.; (US).
SANTORELLI, Gina, M.; (US).
LEEMAN, Aaron, H.; (US).
MALETIC, Milana; (US).
GU, Xin; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/599,361 06.08.2004 US
Title (EN) SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1
(FR) COMPOSÉS DE SULFONYLE COMME INHIBITEURS DE LA 11-BÉTA-HYDROXYSTÉROIDE DÉSHYDROGÉNASE-1
Abstract: front page image
(EN)Sulfonyl derivatives of structural formula I are selective inhibitors of the 11&bgr;-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome or Syndrome X, and other symptoms associated with NIDDM.
(FR)Les dérivatifs de la formule structurelle I sont des inhibiteurs sélectifs de la 11ß-hydroxystéroide déshydrogénase-1. Ces composés sont utiles pour le traitement du diabète, notamment le diabète non insulino-dépendant (DNID), l’hyperglycémie, l’obésité, l’insulinorésistance, la dyslipidémie, l’hyperlipidémie, l’hypertension, le syndrome métabolique ou syndrome X et autres symptômes associés au DNID.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)