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1. (WO2006017540) PILOCARPINE COMPOSITIONS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/017540    International Application No.:    PCT/US2005/027497
Publication Date: 16.02.2006 International Filing Date: 02.08.2005
IPC:
A61K 8/19 (2006.01), A61K 8/40 (2006.01), A61K 8/41 (2006.01), A61K 9/20 (2006.01), A61K 9/68 (2006.01)
Applicants: TRANSORAL PHARMACEUTICALS, INC. [US/US]; 300 Tamal Plaza, Suite 220, Corte Madera, CA 94925 (US) (For All Designated States Except US).
SINGH, Nikhilesh N. [US/US]; (US) (For US Only)
Inventors: SINGH, Nikhilesh N.; (US)
Agent: KEZER, William B.; Townsend and Townsend and Crew LLP, Two Embarcadero Center, 8th Floor, San Francisco, CA 94111 (US)
Priority Data:
60/598,625 03.08.2004 US
11/195,567 01.08.2005 US
Title (EN) PILOCARPINE COMPOSITIONS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS DE PILOCARPINE ET PROCEDES D'UTILISATION ASSOCIES
Abstract: front page image
(EN)The present invention provides novel compositions for the delivery of pilocarpine or a pharmaceutically acceptable salt thereof across the oral mucosa, preferably across the buccal mucosa. In particular, the buffer systems in the compositions of the present invention contain an amount of a strong base that is less than the amount of a weak base, thereby increasing the stability of compositions such as chewing gum compositions and raising the pH of saliva to a pH greater than about 7.5 to facilitate the substantially complete conversion of pilocarpine from its ionized to its un-ionized form. Methods for using the compositions of the present invention for treating conditions such as dry mouth are also provided.
(FR)L'invention concerne des nouvelles compositions destinées à la distribution de pilocarpine ou d'un sel acceptable sur le plan pharmaceutique de celle-ci sur la muqueuse orale, de préférence sur la muqueuse buccale. En particulier, les systèmes tampon présents dans les compositions de l'invention contiennent une quantité d'une base forte inférieure à la quantité d'une base faible, ce qui permet d'augmenter la stabilité de compositions de type compositions de chewing-gum et d'élever le pH de la salive à un pH supérieur à environ 7,5 afin de faciliter la conversion sensiblement complète de pilocarpine de sa forme ionisée à sa forme non ionisée. L'invention concerne également des procédés d'utilisation desdites compositions pour le traitement d'états de type sécheresse de la bouche.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)