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1. (WO2006015985) HIV INHIBITING 1,2,4-TRIAZIN-6-ONE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/015985    International Application No.:    PCT/EP2005/053936
Publication Date: 16.02.2006 International Filing Date: 10.08.2005
IPC:
C07D 253/06 (2006.01), A61K 31/53 (2006.01), A61P 31/18 (2006.01)
Applicants: JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE) (For All Designated States Except US).
ARTS, Frank, Xavier, Jozef, Herwig [BE/BE]; (BE) (For US Only).
HOORNAERT, Georges, Joseph, Cornelius [BE/BE]; (BE) (For US Only).
KILONDA, Amuri [BE/BE]; (BE) (For US Only).
HEERES, Jan [NL/BE]; (BE) (For US Only).
LEWI, Paulus, Joannes [BE/BE]; (BE) (For US Only).
DE JONGE, Marc, René [NL/NL]; (BE) (For US Only).
DAEYAERT, Frederik, Frans, Desiré [BE/BE]; (BE) (For US Only).
VINKERS, Hendrik, Maarten [NL/BE]; (BE) (For US Only).
KOYMANS, Lucien, Maria, Henricus [NL/BE]; (BE) (For US Only)
Inventors: HOORNAERT, Georges, Joseph, Cornelius; (BE).
KILONDA, Amuri; (BE).
HEERES, Jan; (BE).
LEWI, Paulus, Joannes; (BE).
DE JONGE, Marc, René; (BE).
DAEYAERT, Frederik, Frans, Desiré; (BE).
VINKERS, Hendrik, Maarten; (BE).
KOYMANS, Lucien, Maria, Henricus; (BE).
JANSSEN, Paul, Adriaan, Jan;
Common
Representative:
JANSSEN PHARMACEUTICA N.V.; Turnhoutseweg 30, B-2340 Beerse (BE)
Priority Data:
04103858.9 10.08.2004 EP
Title (EN) HIV INHIBITING 1,2,4-TRIAZIN-6-ONE DERIVATIVES
(FR) DÉRIVÉS DE 1,2,4-TRIAZIN-6-ONE INHIBITEURS DU VIH
Abstract: front page image
(EN)The present invention relates to HIV replication inhibitors of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1 to 4; R1 represents hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxy C1-6alkylcarbonyl substituted with C1-6alkyloxycarbonyl; their use as a medicine, their use for the manufacture of a medicament for the treatment or the prevention of HIV infection; their processes for preparation and pharmaceutical compositions comprising them.
(FR)La présente invention porte sur des inhibiteurs de réplication du VIH de la formule (I), un oxyde N, un sel d’addition acceptable pharmaceutiquement, un amine quaternaire ou une forme isomère stéréochimique de celui-ci, où l’anneau A et l’anneau B représentent le phényle, le pyridyle, le pyridazinyle, le pyrimidinyle ou le pyrazinyle ; n et m sont 1 à 4; R1 représente l’hydrogène ; un aryle ; un formyle ; un alkyle carbonyle C1-6 ; un alkyloxycarbonyle C1-6 ; éventuellement un alkyle substitué C1-6 ; un alkyloxy C1-6 alkyle carbonyle C1-6 substitué par un alkyloxycarbonyle C1-6 ; leur utilisation comme médicament, leur utilisation pour la fabrication d’un médicament pour le traitement ou la prévention de l’infection VIH ; leurs procédés de fabrication et les compositions pharmaceutiques les comprenant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)