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1. (WO2006015882) TREATMENT OF HYPERPROLIFERATIVE DISEASE WITH SUPERANTIGENS IN COMBINATION WITH ANOTHER ANTICANCER AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/015882 International Application No.: PCT/EP2005/008815
Publication Date: 16.02.2006 International Filing Date: 12.08.2005
Chapter 2 Demand Filed: 09.03.2006
IPC:
C07K 14/31 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
305
from Micrococcaceae (F)
31
from Staphylococcus (G)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants: HEDLUND, Gunnar[SE/SE]; SE (UsOnly)
FORSBERG, Göran[SE/SE]; SE (UsOnly)
WALLÉN-ÖHMAN, Marie[SE/SE]; SE (UsOnly)
ACTIVE BIOTECH AB[SE/SE]; Scheelevägen 22 Box 724 S-220 07 Lund, SE (AllExceptUS)
Inventors: HEDLUND, Gunnar; SE
FORSBERG, Göran; SE
WALLÉN-ÖHMAN, Marie; SE
Agent: AWAPATENT AB; Box 5117 S-200 71 Malmö, SE
Priority Data:
0402025-113.08.2004SE
60/601,54813.08.2004US
Title (EN) TREATMENT OF HYPERPROLIFERATIVE DISEASE WITH SUPERANTIGENS IN COMBINATION WITH ANOTHER ANTICANCER AGENT
(FR) TRAITEMENT DES MALADIES HYPERPROLIFÉRANTES À L’AIDE DE SUPER-ANTIGÈNES COMBINÉS À UN AUTRE AGENT ANTICANCÉREUX
Abstract:
(EN) The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor­ targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody re­sponse and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent pro­vides enhanced therapeutic effects in a treated animal.
(FR) Cette invention a pour objet des procédés de traitement des mammifères souffrant, par exemple, de maladie hyperproliférante comme le cancer, par administration d’un super-antigène ciblant la tumeur et d’un agent chimiothérapeutique, l’administration de ceux-ci permettant de réduire la réponse des anticorps et de développer la réponse du lymphocyte T. Le super-antigène, de type sauvage ou modifié, est mêlé à un groupe caractéristique de recherche de cible, tel qu’un anticorps ou un fragment actif d’anticorps. L’administration combinée d’un super-antigène et d’un agent chimiothérapeutique a, sur un animal traité, des effets thérapeutiques améliorés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)