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1. (WO2006015859) TRIFLUOROMETHYL SUBSTITUTED BENZAMIDES AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/015859 International Application No.: PCT/EP2005/008695
Publication Date: 16.02.2006 International Filing Date: 10.08.2005
IPC:
C07D 217/02 (2006.01) ,C07D 239/74 (2006.01) ,C07D 277/62 (2006.01) ,C07D 237/30 (2006.01) ,C07D 239/84 (2006.01) ,A61K 31/472 (2006.01) ,A61K 31/428 (2006.01) ,A61P 35/00 (2006.01)
Applicants: CARAVATTI, Giorgio[CH/CH]; CH (UsOnly)
FURET, Pascal[FR/FR]; FR (UsOnly)
IMBACH, Patricia[CH/CH]; CH (UsOnly)
MARTINY-BARON, Georg[DE/DE]; DE (UsOnly)
PEREZ, Lawrence, Blas[US/US]; US (UsOnly)
SHENG, Tao[CA/US]; US (UsOnly)
NOVARTIS AG[CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
NOVARTIS PHARMA GMBH[AT/AT]; Brunner Strasse 59 A-1230 Vienna, AT (AT)
Inventors: CARAVATTI, Giorgio; CH
FURET, Pascal; FR
IMBACH, Patricia; CH
MARTINY-BARON, Georg; DE
PEREZ, Lawrence, Blas; US
SHENG, Tao; US
Agent: DE WEERD, Peter ; Novartis AG Corporate Intellectual Property CH-4002 Basel, CH
Priority Data:
0417905.711.08.2004GB
Title (EN) TRIFLUOROMETHYL SUBSTITUTED BENZAMIDES AS KINASE INHIBITORS
(FR) BENZAMIDES SUBSTITUÉS TRIFLUOROMÉTHYLE COMME INHIBITEURS DE KINASE
Abstract: front page image
(EN) The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of phar­maceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.
(FR) L’invention porte sur des composés benzamides substitués trifluorométhyle de la formule (I), des produits pharmaceutiques comprenant ces composés, leur utilisation comme ou pour la fabrication de produits phar­maceutiques, en particulier comme inhibiteurs de kinases de protéine et/ou pour le traitement d’une condition, d’un trouble ou d’une maladie résultant d’une activité kinase de protéine et/ou une maladie proliférative, des procédés de traitement comprenant l’administration des composés, surtout de traitement thérapeutique et prophylactique, des procédés de fabrication des composés et produits intermédiaires novateurs et des phases partielles pour leur synthèse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)