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Pub. No.: WO/2006/015346 International Application No.: PCT/US2005/027339
Publication Date: 09.02.2006 International Filing Date: 29.07.2005
C07H 21/00 (2006.01) ,C07H 21/02 (2006.01) ,C07H 21/04 (2006.01)
Applicants: LIN, Ko-Chung[US/US]; US (UsOnly)
LI, Wensen[US/US]; US (UsOnly)
LIN, Chunhui[--/--]; TW (UsOnly)
WEIN, Yungshun[--/--]; TW (UsOnly)
LAI, Yuliang[--/--]; TW (UsOnly)
KAO, Kuo-His[--/--]; TW (UsOnly)
LU, Mei-Ying[--/--]; TW (UsOnly)
PHARMAESSENTIA CORP.[--/--]; 13F, No. 3 YuanQu St. NanKang District Taipei 115, TW (AllExceptUS)
Inventors: LIN, Ko-Chung; US
LI, Wensen; US
LIN, Chunhui; TW
WEIN, Yungshun; TW
LAI, Yuliang; TW
KAO, Kuo-His; TW
LU, Mei-Ying; TW
Agent: TSAO, Y., Rocky; Fish & Richardson P.C. 225 Franklin Street Boston, MA 02110-2804, US
Priority Data:
Abstract: front page image
(EN) This invention relates to a process of stereoselectively synthesizing an alcohol of the following formula: (I) wherein Rl, R2, R3, R4, and R5 are defined in the specification. The process includes reacting (R) 4-formyl-2,2-dimethyldioxolane with &agr;-bromoacetate in the presence of Zn and a Zn activating agent.
(FR) Cette invention concerne un procédé de synthèse stéréosélective d'un alcool de formule suivante : (I) dans laquelle Rl, R2, R3, R4 et R5 sont définis dans la description. Le procédé comprend de faire réagir du(R)-4-formyl-2,2-diméthyldioxolane avec un &agr;-bromoacétate en présence de Zn et d'un agent activant Zn.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)