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1. (WO2006014913) INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/014913    International Application No.:    PCT/US2005/026419
Publication Date: 09.02.2006 International Filing Date: 26.07.2005
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01), C07D 207/12 (2006.01), C07D 207/22 (2006.01), C07D 239/32 (2006.01), C07D 239/42 (2006.01), C07D 239/47 (2006.01), C07D 239/48 (2006.01), C07D 239/50 (2006.01), A61K 31/4015 (2006.01), A61K 31/506 (2006.01), A61K 31/4025 (2006.01)
Applicants: BIOCRYST PHARMACEUTICALS, INC. [US/US]; Suite B, 2190 Parkway Lake Drive, Birmingham, Alabama 35244-1879 (US) (For All Designated States Except US).
BABU, Yarlagadda S. [IN/US]; (US) (For US Only).
KAMATH, Vivekanand P. [CA/US]; (US) (For US Only).
MORRIS, JR., Philip E. [US/US]; (US) (For US Only)
Inventors: BABU, Yarlagadda S.; (US).
KAMATH, Vivekanand P.; (US).
MORRIS, JR., Philip E.; (US)
Agent: PETERSON, T. Gregory; One Federal Place, 1819 Fifth Avenue North, Birmingham, Alabama 35203-2104 (US)
Priority Data:
60/591,442 27.07.2004 US
60/619,126 15.10.2004 US
Title (EN) INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE
(FR) INHIBITEURS DE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE ET 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE
Abstract: front page image
(EN)Described are compounds of the general formula (I), VI and (VII). Also described are pharmaceutical compositions comprising the compounds identified. The compounds and pharmaceutical compositions described are inhibitors of 5'-methylthioadenosine/S-adenosylhomocystein nucleosidase (MTAN) and/or 5'-methylthioadenosine phosphorylase (MTAP). Methods of treatment using the compounds and pharmaceutical compositions described are also provided for preventing and/or treating disease states and/or conditions by inhibiting MTAN and/or MTAP in patients.
(FR)L'invention porte sur des composés représentés par la formule (I), VI et (VII). Elle concerne aussi des compositions pharmaceutiques contenant les composés identifiés. Ces composés et ces compositions pharmaceutiques sont des inhibiteurs de 5'-methylthioadenosine/S-adenosylhomocystein nucleosidase (MTAN) et/ou 5'-methylthioadenosine phosphorylase (MTAP). L'invention port aussi sur des procédés de traitement utilisant les composés et les compositions pharmaceutiques afin d'empêcher et/ou de traiter des maladies et/ou des conditions par inhibition de MTAN et/ou MTAP chez des patients.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)