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Machine translation
1. (WO2006014899) PROCESS FOR IMPROVED PROTEIN EXPRESSION BY STRAIN ENGINEERING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/014899    International Application No.:    PCT/US2005/026390
Publication Date: 09.02.2006 International Filing Date: 26.07.2005
IPC:
C12P 21/06 (2006.01)
Applicants: DOW GLOBAL TECHNOLOGIES INC. [US/US]; Washington Street, 1790 Building, Midland, MI 48674 (US) (For All Designated States Except US).
RAMSEIER, Thomas, M. [US/US]; (US) (For US Only).
JIN, Hongfan [US/US]; (US) (For US Only).
SQUIRES, Charles, H. [US/US]; (US) (For US Only)
Inventors: RAMSEIER, Thomas, M.; (US).
JIN, Hongfan; (US).
SQUIRES, Charles, H.; (US)
Agent: KNOWLES, Sherry, M.; King & Spalding LLP, 191 Peachtree Street, 45th Floor, Atlanta, GA 30303-1763 (US)
Priority Data:
60/591,489 26.07.2004 US
Title (EN) PROCESS FOR IMPROVED PROTEIN EXPRESSION BY STRAIN ENGINEERING
(FR) PROCEDE PERMETTANT D'AMELIORER L'EXPRESSION D'UNE PROTEINE PAR MISE AU POINT D'UNE SOUCHE PAR GENIE GENETIQUE
Abstract: front page image
(EN)This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
(FR)L'invention concerne un procédé permettant d'améliorer les niveaux de production de protéines de combinaison ou de peptides ou d'améliorer le niveau de protéines de combinaison actives ou de peptides exprimés dans des cellules hôtes. L'invention concerne un procédé permettant de comparer deux profils génétiques d'une cellule qui exprime une protéine de combinaison et de modifier cette cellule afin de modifier l'expression d'un produit génique qui est régulé en hausse en réponse à l'expression de la protéine de recombinaison. Ledit procédé permet d'améliorer la production ou la qualité d'une protéine, par exemple, par augmentation de la solubilité d'une protéine de recombinaison.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)