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1. WO2006014877 - POTASSIUM CHANNEL INHIBITORS

Publication Number WO/2006/014877
Publication Date 09.02.2006
International Application No. PCT/US2005/026337
International Filing Date 25.07.2005
IPC
C07D 401/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
A61K 31/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
CPC
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
C07D 213/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
C07D 213/61
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
61Halogen atoms or nitro radicals
C07D 213/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
63One oxygen atom
64attached in position 2 or 6
C07D 213/73
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
73Unsubstituted amino or imino radicals
Applicants
  • MERCK & CO., INC. [US]/[US] (AllExceptUS)
  • BILODEAU, Mark, T. [US]/[US] (UsOnly)
  • DINSMORE, Christopher, J. [US]/[US] (UsOnly)
  • BERGMAN, Jeffrey, M. [US]/[US] (UsOnly)
  • TROTTER, B. Wesley [US]/[US] (UsOnly)
  • NEILSON, Lou Anne [US]/[US] (UsOnly)
  • WU, Zhicai [CN]/[US] (UsOnly)
  • MANLEY, Peter [US]/[US] (UsOnly)
  • HARTNETT, John [US]/[US] (UsOnly)
Inventors
  • BILODEAU, Mark, T.
  • DINSMORE, Christopher, J.
  • BERGMAN, Jeffrey, M.
  • TROTTER, B. Wesley
  • NEILSON, Lou Anne
  • WU, Zhicai
  • MANLEY, Peter
  • HARTNETT, John
Common Representative
  • MERCK & CO., INC.
Priority Data
60/592,24229.07.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) POTASSIUM CHANNEL INHIBITORS
(FR) INHIBITEURS DE CANAUX POTASSIQUES
Abstract
(EN) The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
(FR) L'invention concerne des composés présentant une structure (I) et utilisés en tant qu'inhibiteurs de canaux potassiques pour traiter les arythmies cardiaques et analogues.
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