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1. WO2006014836 - METHOD FOR TUMOR PERFUSION ASSESSMENT IN CLINICAL TRIALS USING DYNAMIC CONTRAST ENHANCED MRI

Publication Number WO/2006/014836
Publication Date 09.02.2006
International Application No. PCT/US2005/026186
International Filing Date 22.07.2005
Chapter 2 Demand Filed 28.02.2006
IPC
A61B 5/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
05Measuring for diagnosis by means of electric currents or magnetic fields
CPC
A61B 5/055
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
055involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
Applicants
  • VIRTUALSCOPICS, LLC [US]/[US] (AllExceptUS)
  • ASHTON, Edward [US]/[US] (UsOnly)
Inventors
  • ASHTON, Edward
Agents
  • GREENBAUM, Michael, C.
Priority Data
10/901,16029.07.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR TUMOR PERFUSION ASSESSMENT IN CLINICAL TRIALS USING DYNAMIC CONTRAST ENHANCED MRI
(FR) PROCEDE POUR EVALUATION DE PERFUSION TUMORALE EN ESSAIS CLINIQUES SOUS IRM AMELIOREE PAR CONTRASTE DYNAMIQUE
Abstract
(EN) In a clinical trial using dceMRI, the assessment of tumor perfusion has problems of noise and reproducibility. To address those problems, an end-to-end method develops and enforces a standard imaging protocol, ensures site compliance both by pre-qualification and throughout the trial, ensures that the scanners function properly both at the outset and throughout the trial, develops an analysis process with automation and quality control to prevent human error, and provides analysis software to perform the assessment and to provide an electronic audit trail.
(FR) S'agissant d'essais cliniques sous IRM améliorée par contraste dynamique, l'évaluation de perfusion tumorale pose des problèmes de bruit et de reproductibilité. Afin d'y remédier, on décrit un procédé de bout en bout qui permet d'établir et d'appliquer un protocole d'imagerie normalisé, d'assurer la conformité de site en phase de préqualification et tout au long des essais, de garantir que les dispositifs d'exploration fonctionnent correctement dès le départ et durant les essais, de créer un processus d'analyse sous automatisation et contrôle de qualité visant à éviter les erreurs humaines, et de fournir un logiciel d'analyse pour conduire l'évaluation et livrer une piste de vérification.
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