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1. WO2006014787 - COMPOSITIONS CONTAINING POLICOSANOL AND B VITAMINS AND THEIR PHARMACEUTICAL USES

Publication Number WO/2006/014787
Publication Date 09.02.2006
International Application No. PCT/US2005/025943
International Filing Date 25.07.2005
IPC
A61K 31/714 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7135Compounds containing heavy metals
714Cobalamins, e.g. cyanocobalamin, vitamin B12
A61K 31/525 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
525Isoalloxazines, e.g. riboflavins, vitamin B2
A61K 31/4415 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4415Pyridoxine, i.e.vitamin B6
A61K 31/045 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61P 3/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
CPC
A61K 31/045
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/4415
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4415Pyridoxine, i.e. Vitamin B6
A61K 31/525
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
525Isoalloxazines, e.g. riboflavins, vitamin B2
A61K 31/714
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7135Compounds containing heavy metals
714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • BERLIN, Roger [US]/[US] (UsOnly)
Inventors
  • BERLIN, Roger
Agents
  • FLYNN, Steven, H.
Priority Data
10/900,04027.07.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS CONTAINING POLICOSANOL AND B VITAMINS AND THEIR PHARMACEUTICAL USES
(FR) COMPOSITIONS CONTENANT DU POLICOSANOL ET DES VITAMINES B ET LEURS UTILISATIONS PHARMACEUTIQUES
Abstract
(EN) A composition is provided which contains policosanol and B vitamins and which may be used for treating and or reducing hypercholesterolemia and hyperhomocysteinemia diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, Lp(a), triglycerides, homocysteine, coronary heart disease (heart attacks and strokes), carotid artery disease, inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, anxiety, depression, neurodegenerative disorders (such as but not limited to Alzheimers), and/or raise HDL cholesterol in humans and animals. The method comprises administering policosanol and B vitamins which together effectively lower the risk of heart disease. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to B vitamins.
(FR) L'invention concerne une composition qui contient du policosanol et des vitamines B et qui peut être utilisée pour traiter ou réduire l'hypercholestérolémie et les maladies liées à l'hypercholestérolémie, le cholestérol total, le cholestérol LDL, le rapport LDL/HDL, la Lp(a), les triglycérides, l'homocystéine, la maladie coronarienne (les crises cardiaques et les accidents vasculaires cérébraux), la maladie de l'artère carotide, l'inflammation, la thrombose veineuse profonde, les maladies immunorégulatrices, les maladies cardiovasculaires, l'anxiété, la dépression, les troubles neurodégénératifs (notamment la maladie d'Alzheimer) et/ou pour élever le taux de cholestérol HDL chez les humains et les animaux. La méthode selon l'invention consiste à administrer du policosanol et des vitamines B qui ensemble réduisent efficacement les risques de maladie du coeur. Généralement, la composition administrée comprend en poids environ 0,1-10 parties de policosanol pour 1 partie de vitamines B.
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