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1. (WO2006014703) HOMOPIPERDININE DERIVATIVES AS NK-1 ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/014703    International Application No.:    PCT/US2005/025688
Publication Date: 09.02.2006 International Filing Date: 20.07.2005
IPC:
A61P 25/00 (2006.01), A61K 31/55 (2006.01), C07D 223/04 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P. O. Box 4000, Route 206 and Provinceline Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
WU, Yong-Jin [CA/US]; (US) (For US Only).
HE, Huan [CN/US]; (US) (For US Only)
Inventors: WU, Yong-Jin; (US).
HE, Huan; (US)
Agent: ALGIERI, Aldo; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
60/589,729 20.07.2004 US
Title (EN) HOMOPIPERDININE DERIVATIVES AS NK-1 ANTAGONISTS
(FR) DERIVES DE HOMOPIPERIDINE EN TANT QU'ANTAGONISTES NK-1
Abstract: front page image
(EN)The present disclosure relates to chemical compounds and their use in human therapy. In a specific embodiment, compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said compounds (I) useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.
(FR)La présente invention a trait à des composés chimiques et leur utilisation dans la thérapie humaine. Dans un mode de réalisation spécifique, des composés de formule (I) ou un isomère, un sel ou solvate pharmaceutiquement acceptable de ceux-ci ou une formulation pharmaceutiquement acceptable comportant lesdits composés (I) utiles pour le traitement ou la prévention de conditions induites par des tachykinines et/ou l'inhibition sélective de la protéine transporteuse de recaptage de la sérotonine. Les composés présentent une action double en tant qu'antagonistes NK-1 et inhibiteurs sélectifs de recaptage de la sérotonine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)